Abstract：
A simple, solvent-free arginine-catalyzed aldol dimerization of levulinic acid was achieved via the simultaneous formation of a eutectic mixture. Dimers of levulinic acid are valued as biomass-derived fine chemical precursors, with potential to upgrade to bio-jet fuels or N-containing functional chemicals. Typically, these dimers are produced as isomeric mixtures using high temperatures and a variety of solid inorganic catalysts or mineral acids. In this study, an organocatalytic and regioselective dimerization was achieved at 22 % conversion on either a bench or kilogram scale using mild temperatures and only L-arginine as both a co-solvent and catalyst. The intricate H-bonding network comprising the eutectic solvent was harnessed to produce only one product, minimizing side reactivity and preserving the reactants for recycling.
摘要：
一个简单的，通过同时形成低共熔混合物，实现了无溶剂精氨酸催化的乙酰丙酸醛醇二聚。乙酰丙酸的二聚体被认为是生物质衍生的精细化学前体，有可能升级到生物喷气燃料或含N功能性化学品。通常,这些二聚体使用高温和各种固体无机催化剂或无机酸作为异构体混合物生产。在这项研究中,使用温和的温度和仅L-精氨酸作为共溶剂和催化剂,在台架或千克规模上以22%的转化率实现有机催化和区域选择性二聚。利用包含共晶溶剂的复杂的H键网络仅生产一种产品，最大限度地减少侧反应性和保存反应物的循环。
