Abstract：
BACKGROUND: Urinary tract infections (UTIs) are the most common type of nosocomial infection and severe health issues because of the difficulties and frequent recurrence. Today, alternative methods such as sonodynamic therapy (SDT), photodynamic therapy (PDT) and herbal materials use for treating infections like UTI in many countries.
METHODS: We conducted searches of the biomedical databases (Google Scholar, Scopus, PubMed, and Web of sciences) to identify related studies from 2008 to 2023.
RESULTS: SDT aims to use ultrasound to activate a sonosensitizer, which causes a biological effect by raising reactive oxygen species (ROS). When bacteria are exposed to ROS, several important effects occur: oxidative damage, DNA damage, protein dysfunction etc. SDT with herbal medicine significantly reduced the number of colony-forming units and bactericidal activity for Klebsiella pneumonia and E. coli. PDT is a promising treatment for cancer and microbial infections, combining a photosensitiser, light and tissue molecular oxygen. It involves a photosensitizer, light source, and oxygen, with variations affecting microbial binding and bactericidal activity. Factors affecting antibacterial properties include plant type, growing conditions, harvesting, and processing. This review highlights the recent advancements in sonodynamic, photodynamic, herbal, and bio-material-based approaches in the treatment of E. coli infections.
CONCLUSIONS: These alternative therapies offer exciting prospects for addressing UTIs, especially in cases where traditional antibiotic treatments may be less effective. Further research and clinical studies are warranted to fully explore the potential of these innovative treatment modalities in combating UTIs and improving patient outcomes.
METHODS: We conducted searches of the biomedical databases (Google Scholar, Scopus, PubMed, and Web of sciences) to identify related studies from 2008 to 2023.
RESULTS: SDT aims to use ultrasound to activate a sonosensitizer, which causes a biological effect by raising reactive oxygen species (ROS). When bacteria are exposed to ROS, several important effects occur: oxidative damage, DNA damage, protein dysfunction etc. SDT with herbal medicine significantly reduced the number of colony-forming units and bactericidal activity for Klebsiella pneumonia and E. coli. PDT is a promising treatment for cancer and microbial infections, combining a photosensitiser, light and tissue molecular oxygen. It involves a photosensitizer, light source, and oxygen, with variations affecting microbial binding and bactericidal activity. Factors affecting antibacterial properties include plant type, growing conditions, harvesting, and processing. This review highlights the recent advancements in sonodynamic, photodynamic, herbal, and bio-material-based approaches in the treatment of E. coli infections.
CONCLUSIONS: These alternative therapies offer exciting prospects for addressing UTIs, especially in cases where traditional antibiotic treatments may be less effective. Further research and clinical studies are warranted to fully explore the potential of these innovative treatment modalities in combating UTIs and improving patient outcomes.
摘要：
背景：尿路感染（UTI）是最常见的医院感染类型，并且由于困难和频繁复发而导致严重的健康问题。今天,替代方法，如声动力疗法(SDT)，在许多国家，光动力疗法（PDT）和草药材料用于治疗UTI等感染。
方法：我们对生物医学数据库进行了搜索(谷歌学者，Scopus,PubMed,和WebofSciences)确定2008-2023年的相关研究。
结果：SDT旨在使用超声波激活声敏剂，通过提高活性氧（ROS）引起生物效应。当细菌暴露于ROS时，发生了几个重要的影响：氧化损伤，DNA损伤,蛋白质功能障碍等.使用草药的SDT显着降低了菌落形成单位的数量和对肺炎克雷伯菌和大肠杆菌的杀菌活性。PDT是一种很有前途的治疗癌症和微生物感染，结合光敏剂，光和组织分子氧。它涉及光敏剂，光源,和氧气,变化会影响微生物结合和杀菌活性。影响抗菌性能的因素包括植物类型，生长条件,收获,和处理。这篇综述强调了声动力学的最新进展，光动力，草药,和基于生物材料的方法治疗大肠杆菌感染。
结论：这些替代疗法为解决尿路感染提供了令人兴奋的前景，尤其是在传统抗生素治疗可能不太有效的情况下。需要进一步的研究和临床研究，以充分探索这些创新治疗方式在对抗尿路感染和改善患者预后方面的潜力。
方法：我们对生物医学数据库进行了搜索(谷歌学者，Scopus,PubMed,和WebofSciences)确定2008-2023年的相关研究。
结果：SDT旨在使用超声波激活声敏剂，通过提高活性氧（ROS）引起生物效应。当细菌暴露于ROS时，发生了几个重要的影响：氧化损伤，DNA损伤,蛋白质功能障碍等.使用草药的SDT显着降低了菌落形成单位的数量和对肺炎克雷伯菌和大肠杆菌的杀菌活性。PDT是一种很有前途的治疗癌症和微生物感染，结合光敏剂，光和组织分子氧。它涉及光敏剂，光源,和氧气,变化会影响微生物结合和杀菌活性。影响抗菌性能的因素包括植物类型，生长条件,收获,和处理。这篇综述强调了声动力学的最新进展，光动力，草药,和基于生物材料的方法治疗大肠杆菌感染。
结论：这些替代疗法为解决尿路感染提供了令人兴奋的前景，尤其是在传统抗生素治疗可能不太有效的情况下。需要进一步的研究和临床研究，以充分探索这些创新治疗方式在对抗尿路感染和改善患者预后方面的潜力。
