PDF(Pubmed)
Abstract：
BACKGROUND: World Health Organisation (WHO) and USA Centers for Disease Control and Prevention (U.S. CDC) recommendations now allow simultaneous administration of COVID-19 and other vaccines. We compared antibody responses after coadministration of influenza and bivalent COVID-19 vaccines in the same (ipsilateral) arm vs. different (contralateral) arms.
METHODS: Pre- and post-vaccination serum samples from individuals in the Prospective Assessment of COVID-19 in a Community (PACC) cohort were used to conduct haemaglutination inhibition (HI) assays with the viruses in the 2022-2023 seasonal influenza vaccine and focus reduction neutralisation tests (FRNT) using a BA.5 SARS-CoV-2 virus. The effect of ipsilateral vs. contralateral vaccination on immune responses was inferred in a model that accounted for higher variance in vaccine responses at lower pre-vaccination titers.
RESULTS: Ipsilateral vaccination did not cause higher influenza vaccine responses compared to contralateral vaccination. The response to SARS-CoV-2 was slightly increased in the ipsilateral group, but equivalence was not excluded.
CONCLUSIONS: Coadministration of influenza and bivalent COVID-19 vaccines in the same arm or different arms did not strongly influence the antibody response to either vaccine.
BACKGROUND: This work was supported by the U.S. CDC (grant number: 75D30120C09259).
METHODS: Pre- and post-vaccination serum samples from individuals in the Prospective Assessment of COVID-19 in a Community (PACC) cohort were used to conduct haemaglutination inhibition (HI) assays with the viruses in the 2022-2023 seasonal influenza vaccine and focus reduction neutralisation tests (FRNT) using a BA.5 SARS-CoV-2 virus. The effect of ipsilateral vs. contralateral vaccination on immune responses was inferred in a model that accounted for higher variance in vaccine responses at lower pre-vaccination titers.
RESULTS: Ipsilateral vaccination did not cause higher influenza vaccine responses compared to contralateral vaccination. The response to SARS-CoV-2 was slightly increased in the ipsilateral group, but equivalence was not excluded.
CONCLUSIONS: Coadministration of influenza and bivalent COVID-19 vaccines in the same arm or different arms did not strongly influence the antibody response to either vaccine.
BACKGROUND: This work was supported by the U.S. CDC (grant number: 75D30120C09259).
摘要：
背景：世界卫生组织（WHO）和美国疾病控制和预防中心（美国CDC）的建议现在允许同时施用COVID-19和其他疫苗。我们比较了在同一（同侧）臂中同时施用流感和二价COVID-19疫苗后的抗体反应与不同的（对侧）手臂。
方法：在社区COVID-19前瞻性评估（PACC）队列中，来自个体的疫苗接种前后血清样本用于对2022-2023年季节性流感疫苗中的病毒进行血细胞凝集抑制（HI）测定，并使用BA.5SARS-CoV-2病毒进行病灶减少中和试验（FRNT）。同侧与同侧的影响在一个模型中推断了免疫应答的对侧疫苗接种,该模型解释了在较低的疫苗接种前滴度下疫苗应答的较高差异.
结果：同侧疫苗接种与对侧疫苗接种相比没有引起更高的流感疫苗应答。同侧组对SARS-CoV-2的反应略有增加，但不排除等价性。
结论：流感和二价COVID-19疫苗在同一组或不同组中的联合给药不会强烈影响对两种疫苗的抗体反应。
背景：这项工作得到了美国CDC的支持（授权号：75D30120C09259）。
方法：在社区COVID-19前瞻性评估（PACC）队列中，来自个体的疫苗接种前后血清样本用于对2022-2023年季节性流感疫苗中的病毒进行血细胞凝集抑制（HI）测定，并使用BA.5SARS-CoV-2病毒进行病灶减少中和试验（FRNT）。同侧与同侧的影响在一个模型中推断了免疫应答的对侧疫苗接种,该模型解释了在较低的疫苗接种前滴度下疫苗应答的较高差异.
结果：同侧疫苗接种与对侧疫苗接种相比没有引起更高的流感疫苗应答。同侧组对SARS-CoV-2的反应略有增加，但不排除等价性。
结论：流感和二价COVID-19疫苗在同一组或不同组中的联合给药不会强烈影响对两种疫苗的抗体反应。
背景：这项工作得到了美国CDC的支持（授权号：75D30120C09259）。
