{Reference Type}: Journal Article
{Title}: Ipsilateral and contralateral coadministration of influenza and COVID-19 vaccines produce similar antibody responses.
{Author}: Pattinson D;Jester P;Gu C;Guan L;Armbrust T;Petrie JG;King JP;Nguyen HQ;Belongia EA;Halfmann P;Neumann G;Kawaoka Y;
{Journal}: EBioMedicine
{Volume}: 103
{Issue}: 0
{Year}: 2024 May 3
{Factor}: 11.205
{DOI}: 10.1016/j.ebiom.2024.105103
{Abstract}: <B>BACKGROUND: </B>World Health Organisation (WHO) and USA Centers for Disease Control and Prevention (U.S. CDC) recommendations now allow simultaneous administration of COVID-19 and other vaccines. We compared antibody responses after coadministration of influenza and bivalent COVID-19 vaccines in the same (ipsilateral) arm vs. different (contralateral) arms.<BR><B>METHODS: </B>Pre- and post-vaccination serum samples from individuals in the Prospective Assessment of COVID-19 in a Community (PACC) cohort were used to conduct haemaglutination inhibition (HI) assays with the viruses in the 2022-2023 seasonal influenza vaccine and focus reduction neutralisation tests (FRNT) using a BA.5 SARS-CoV-2 virus. The effect of ipsilateral vs. contralateral vaccination on immune responses was inferred in a model that accounted for higher variance in vaccine responses at lower pre-vaccination titers.<BR><B>RESULTS: </B>Ipsilateral vaccination did not cause higher influenza vaccine responses compared to contralateral vaccination. The response to SARS-CoV-2 was slightly increased in the ipsilateral group, but equivalence was not excluded.<BR><B>CONCLUSIONS: </B>Coadministration of influenza and bivalent COVID-19 vaccines in the same arm or different arms did not strongly influence the antibody response to either vaccine.<BR><B>BACKGROUND: </B>This work was supported by the U.S. CDC (grant number: 75D30120C09259).