%0 Journal Article
%T Ipsilateral and contralateral coadministration of influenza and COVID-19 vaccines produce similar antibody responses.
%A Pattinson D
%A Jester P
%A Gu C
%A Guan L
%A Armbrust T
%A Petrie JG
%A King JP
%A Nguyen HQ
%A Belongia EA
%A Halfmann P
%A Neumann G
%A Kawaoka Y
%J EBioMedicine
%V 103
%N 0
%D 2024 May 3
%M 38574407
%F 11.205
%R 10.1016/j.ebiom.2024.105103
%X <B>BACKGROUND: </B>World Health Organisation (WHO) and USA Centers for Disease Control and Prevention (U.S. CDC) recommendations now allow simultaneous administration of COVID-19 and other vaccines. We compared antibody responses after coadministration of influenza and bivalent COVID-19 vaccines in the same (ipsilateral) arm vs. different (contralateral) arms.<BR><B>METHODS: </B>Pre- and post-vaccination serum samples from individuals in the Prospective Assessment of COVID-19 in a Community (PACC) cohort were used to conduct haemaglutination inhibition (HI) assays with the viruses in the 2022-2023 seasonal influenza vaccine and focus reduction neutralisation tests (FRNT) using a BA.5 SARS-CoV-2 virus. The effect of ipsilateral vs. contralateral vaccination on immune responses was inferred in a model that accounted for higher variance in vaccine responses at lower pre-vaccination titers.<BR><B>RESULTS: </B>Ipsilateral vaccination did not cause higher influenza vaccine responses compared to contralateral vaccination. The response to SARS-CoV-2 was slightly increased in the ipsilateral group, but equivalence was not excluded.<BR><B>CONCLUSIONS: </B>Coadministration of influenza and bivalent COVID-19 vaccines in the same arm or different arms did not strongly influence the antibody response to either vaccine.<BR><B>BACKGROUND: </B>This work was supported by the U.S. CDC (grant number: 75D30120C09259).