Abstract：
In the 1940s and 1950s, researchers seeking safe and novel ways to eliminate airborne pathogens from enclosed spaces, investigated glycol vapours as a method of disinfection. More recently, the COVID-19 pandemic highlighted the need for a non-toxic aerial disinfectant that can be used in the presence of people. This scoping review is intended to analyse the early and more recent literature on glycol disinfection, scrutinizing the methodologies used, and to determine if the use of glycols as modern-day disinfectants is justified PRISMA-ScR guidelines were used to assess the 749 articles retrieved from the Web of Science platform, with 46 articles retained after the search strategy was applied. Early studies generally demonstrated good disinfection capabilities against airborne bacteria and viruses, particularly with propylene glycol (PG) vapour. Vapour pressure, relative humidity, and glycol concentration were found to be important factors affecting the efficacy of glycol vapours. Contact times depended mainly on the glycol application method (i.e. aerosolization or liquid formulation), although information on how glycol efficacy is impacted by contact time is limited. Triethylene glycol (TEG) is deemed to have low toxicity, carcinogenicity, and mutagenicity and is registered for use in air sanitization and deodorization by the US Environmental Protection Agency. Glycols are also used in liquid formulations for their antimicrobial activity against a wide range of microorganisms, although when used as a non-active excipient in products, their contribution to antimicrobial efficacy is rarely assessed. The appropriate use of liquid glycol-containing formulations was found to positively impact the antimicrobial capabilities of disinfectants when used at temperatures <0, food preservatives, and dental medicaments. Providing modern delivery technology can accurately control environmental conditions, the use of aerosolized glycol formulations should lead to successful disinfection, aiding infection prevention, and control regimens.
摘要：
在1940年代和1950年代，研究人员寻求安全和新颖的方法来消除封闭空间中的空气病原体，研究了乙二醇蒸气作为一种消毒方法。最近,COVID-19大流行强调了对可以在人面前使用的无毒空气消毒剂的需求。这篇范围审查旨在分析早期和最近关于乙二醇消毒的文献，仔细检查使用的方法，并确定使用乙二醇作为现代消毒剂是否合理。PRISMA-ScR指南用于评估从WebofScience平台检索的749篇文章，在应用搜索策略后保留了46篇文章。早期研究通常证明对空气传播的细菌和病毒具有良好的消毒能力，特别是丙二醇（PG）蒸气。蒸汽压力,相对湿度,和乙二醇浓度被发现是影响乙二醇蒸气功效的重要因素。接触时间主要取决于乙二醇的应用方法（即雾化或液体制剂），尽管有关乙二醇功效如何受接触时间影响的信息有限。三甘醇（TEG）被认为具有低毒性，致癌性和致突变性，并由美国环境保护局注册用于空气消毒和除臭。尽管在产品中用作非活性赋形剂，但乙二醇也因其对多种微生物的抗菌活性而用于液体制剂中。它们对抗菌疗效的贡献很少被评估.当在零度以下的温度下使用时，适当使用含液体乙二醇的制剂会对消毒剂的抗菌能力产生积极影响。食品防腐剂和牙科药物。提供现代交付技术可以准确控制环境条件，使用雾化乙二醇制剂应导致成功的消毒，辅助感染预防和控制方案。
