PDF(Pubmed)
Abstract：
How cancer patterns in humans compare to those of other species remains largely unknown and there is an even bigger knowledge gap for rare cancers like male breast cancer. One Health is a convergence of human and animal healthcare that encourages cross-pollination of medical research uniting human and veterinary medicine. Recognising that breast cancer occurs spontaneously in other male species (e.g. primates, canines, felines), and knowing that no laboratory models exist for male breast cancer, which limits our ability to perform functional studies, we explored the feasibility of applying One Health to breast cancer in men by conducting a narrative review of the topic. Spontaneous development of breast cancer was reported in captive male primates and in companion canines and felines. Some parallels in tumour biology of human male breast cancer with canines and primates were found. The age distribution, pattern of biomarker expression and metastasis were similar, with mammary tumours typically detected after two-thirds of average lifespan. However, instances of triple negative and inflammatory breast cancer, which are rarely observed in human male breast cancer, were found in canines and histological classification was inconsistent between species. These disparities need redressing to enable full exploration of the One Health paradigm in rare cancers.
摘要：
人类的癌症模式与其他物种的癌症模式相比在很大程度上仍然未知，对于男性乳腺癌等罕见癌症，还有更大的知识差距。一个健康是人类和动物医疗保健的融合，鼓励将人类和兽医学联合起来的医学研究的交叉授粉。认识到乳腺癌在其他男性物种中自发发生（例如灵长类动物，犬科动物,猫科动物)，知道没有男性乳腺癌的实验室模型，这限制了我们进行功能研究的能力，我们通过对该主题进行叙述性回顾,探讨了将OneHealth应用于男性乳腺癌的可行性.据报道，圈养的雄性灵长类动物以及伴侣犬和猫科动物自发发生乳腺癌。在人类男性乳腺癌与犬和灵长类动物的肿瘤生物学中发现了一些相似之处。年龄分布,生物标志物表达和转移模式相似，通常在平均寿命的三分之二后检测到乳腺肿瘤。然而,三阴性和炎性乳腺癌的实例，这在人类男性乳腺癌中很少观察到，在犬科动物中发现，物种之间的组织学分类不一致。这些差异需要纠正，以便能够全面探索罕见癌症的“单一健康”范式。
