GSNOR 通过 MAPK14 的 S - 亚硝化负调节 NLRP3 炎性体。
关键词: S-nitrosation Colitis GSNOR MAPK14 NLRP3 inflammasome Septic shock
Mesh : Animals Mice Aldehyde Oxidoreductases / metabolism genetics Colitis / chemically induced pathology immunology Dextran Sulfate Inflammasomes / metabolism Interleukin-1beta / metabolism Lipopolysaccharides / pharmacology Macrophages / metabolism immunology Mice, Inbred C57BL Mice, Knockout Nitrosation NLR Family, Pyrin Domain-Containing 3 Protein / metabolism Shock, Septic / metabolism chemically induced Mitogen-Activated Protein Kinase 14 / metabolism
来 源:
DOI:10.1038/s41423-024-01155-9
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