Abstract：
Eimeria media is a principal pathogen responsible for rabbit coccidiosis, targeting the rabbit\'s intestinal epithelial cells. This parasitism damages the intestinal mucosal barrier, initiating a systemic immune and inflammatory response that jeopardizes the sustainable growth of rabbit farming. To understand the implications of infection on the host\'s immune and metabolic responses, we employed RNA-Seq to analyze RNA from the liver and duodenum tissues of post-infected rabbits infected with both the precocious line and wild-type strain of E.media. Comprehensive transcriptomic analysis revealed that the two parasites exhibit divergent transcriptomic imprints on host tissues. While the precocious line predominantly modulates immune-centric pathways with significant differential gene enrichment, wild-type strain favors pathways that affect metabolism. In addition, our study pinpointed a set of genes that undergo significant modifications in response to these effects. These revelations grant a fresh avenue to probe deeper into the symbiotic intricacies of the E.media and its rabbit host.
摘要：
艾美球虫培养基是导致兔球虫病的主要病原体，靶向兔肠上皮细胞。这种寄生虫会破坏肠粘膜屏障，启动系统性免疫和炎症反应，危及兔养殖的可持续增长。了解感染对宿主免疫和代谢反应的影响，我们使用RNA-Seq分析了感染早熟品系和野生型E.media的感染后兔子的肝脏和十二指肠组织的RNA。综合转录组分析表明，这两种寄生虫在宿主组织上表现出不同的转录组印记。虽然早熟系主要调节具有显著差异基因富集的免疫中心途径，野生型菌株有利于影响代谢的途径。此外,我们的研究确定了一组基因，这些基因在对这些效应的反应中经历了显著的修饰。这些启示为深入探究E.media及其兔子宿主的共生复杂性提供了新的途径。
