关键词: Clinical recovery First-episode psychosis Meta-analysis Personal recovery Schizophrenia spectrum disorders

Mesh : Humans Schizophrenia / physiopathology rehabilitation Resilience, Psychological Psychotic Disorders / physiopathology rehabilitation Outcome Assessment, Health Care Schizophrenic Psychology

来  源:   DOI:10.1016/j.schres.2024.03.021

Abstract:
BACKGROUND: The spectrum of schizophrenia disorders (SSD) is a severe mental disorder. It is one of the main medical causes of disability that generates high health and social costs.
OBJECTIVE: To analyze the factors associated with clinical recovery (CR) (symptomatic remission-SR and functional recovery-FR) and personal recovery (PR) in people diagnosed with SSD.
METHODS: 14 meta-analyses focused on recovery were reviewed following the PRISMA model statements. 95 % of CI was established.
RESULTS: Shorter Duration of Untreated Psychosis (Zr = 0.24, [0.17, 0.30]) and total Duration of Untreated Illness (Zr = 0.34, [0.20, 0.48]) were related to greater SR and general functioning, respectively. Resilience was the variable with the greatest effect on FR (Zr = 0.67, [0.63, 0.71]). Premorbid adjustment (Zr = 0.34, [0.18, 0.49]) and physical intervention (Zr = 0.71, [0.55, 0.86]) had the greatest effect on occupational and social functioning, respectively. Less severe affective symptoms were related to greater PR (Zr = 0.46, [0.42, 0.50]). There are differences between affective SR and the other types of SR (Zr(SR-A - SR-) = 0.13, Qb = 6.51, p = 0.011), (Zr(SR-A - SR+) = 0.20, Qb = 8.52, p = 0.004), (Zr(SR-A - SR) = 0.18, Qb = 19.29, p = 0.0001). In all, resilience was associated with greater recovery (Zr = 0.67, [0.53, 0.80]), with the global effect being greater on PR than on CR (Zr(PR-CR) = 0.07, Qb = 3.45, p = 0.05).
CONCLUSIONS: Resilience was the variable most strongly associated with recovery. Symptomatic or functional improvement obtained less statistical weight.
摘要:
背景:精神分裂症(SSD)是一种严重的精神障碍。它是残疾的主要医疗原因之一,会产生高昂的健康和社会成本。
目的:分析SSD患者临床恢复(CR)(症状缓解-SR和功能恢复-FR)和个人恢复(PR)的相关因素。
方法:根据PRISMA模型陈述,回顾了14项集中于恢复的荟萃分析。95%的CI成立。
结果:未治疗精神病的较短持续时间(Zr=0.24,[0.17,0.30])和未治疗疾病的总持续时间(Zr=0.34,[0.20,0.48])与较高的SR和一般功能有关,分别。弹性是对FR影响最大的变量(Zr=0.67,[0.63,0.71])。病前调整(Zr=0.34,[0.18,0.49])和身体干预(Zr=0.71,[0.55,0.86])对职业和社会功能的影响最大,分别。较不严重的情感症状与较高的PR相关(Zr=0.46,[0.42,0.50])。情感SR和其他类型的SR之间存在差异(Zr(SR-A-SR-)=0.13,Qb=6.51,p=0.011),(Zr(SR-A-SR+)=0.20,Qb=8.52,p=0.004),(Zr(SR-A-SR)=0.18,Qb=19.29,p=0.0001)。总之,回弹性与更高的回收率相关(Zr=0.67,[0.53,0.80]),对PR的总体影响大于对CR的影响(Zr(PR-CR)=0.07,Qb=3.45,p=0.05)。
结论:弹性是与恢复最密切相关的变量。症状或功能改善获得的统计权重较小。
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