Abstract：
OBJECTIVE: The purpose of the present study was to evaluate the effect of concentrated growth factor (CGF) on prevention of postoperative complications in the impacted third molar extraction.
METHODS: A total of 25 healthy patients with symmetrical bilaterally impacted third molars (50 extraction sites) were enrolled in this split-mouth, randomized, double-blind clinical trial. Third molar extractions were performed in both sites of the mandible at the same appointment. Randomization was performed using a coin toss to choose the test and control sites. CGF was placed in the extraction socket and the socket was sutured (test group), while the contralateral socket was only sutured (control group). Each patient acted as their own control. The primary outcome were pain assessed by visual analog scale (VAS) and facial swelling on the1st, 3rd and 7th postoperative days. The secondary outcomes were bone healing in extraction sockets through alveolar bone height (ABH) and alveolar bone density (ABD) evaluated by cone beam computed tomography (CBCT) immediately after extraction and in the 3rd and 6th months.
RESULTS: Twenty-five patients (12 female, 13 male; mean age 29.17) with bilateral impacted third molars participated in the study. A statistically significant reduction in pain was determined on the 3rd and 7th postoperative days in the CGF sites compared to the control sites while no statistically significant difference was found between the groups on the 1st postoperative day (3rd day, p = 0.009; 7th day, p = 0.039). There were no statistically significant differences in facial swelling and bone healing between the test and control groups at different time intervals, although the data obtained were slightly favoring the CGF group (p > 0.05). There were no serious adverse effects such as infection, alveolitis, paraesthesia, fracture through the follow-up period in all of the cases.
CONCLUSIONS: The study has demonstrated the effect of CGF on relieving the severity of pain after the third molar extraction.
CONCLUSIONS: Placement of CGF in the extraction socket could relieve postoperative pain and reduce patient discomfort after the third molar extraction. CGF is recommended during the third molar extraction due to its good biological effects, low cost and simple preparation procedures.
BACKGROUND: ChiCTR2300077819.
METHODS: A total of 25 healthy patients with symmetrical bilaterally impacted third molars (50 extraction sites) were enrolled in this split-mouth, randomized, double-blind clinical trial. Third molar extractions were performed in both sites of the mandible at the same appointment. Randomization was performed using a coin toss to choose the test and control sites. CGF was placed in the extraction socket and the socket was sutured (test group), while the contralateral socket was only sutured (control group). Each patient acted as their own control. The primary outcome were pain assessed by visual analog scale (VAS) and facial swelling on the1st, 3rd and 7th postoperative days. The secondary outcomes were bone healing in extraction sockets through alveolar bone height (ABH) and alveolar bone density (ABD) evaluated by cone beam computed tomography (CBCT) immediately after extraction and in the 3rd and 6th months.
RESULTS: Twenty-five patients (12 female, 13 male; mean age 29.17) with bilateral impacted third molars participated in the study. A statistically significant reduction in pain was determined on the 3rd and 7th postoperative days in the CGF sites compared to the control sites while no statistically significant difference was found between the groups on the 1st postoperative day (3rd day, p = 0.009; 7th day, p = 0.039). There were no statistically significant differences in facial swelling and bone healing between the test and control groups at different time intervals, although the data obtained were slightly favoring the CGF group (p > 0.05). There were no serious adverse effects such as infection, alveolitis, paraesthesia, fracture through the follow-up period in all of the cases.
CONCLUSIONS: The study has demonstrated the effect of CGF on relieving the severity of pain after the third molar extraction.
CONCLUSIONS: Placement of CGF in the extraction socket could relieve postoperative pain and reduce patient discomfort after the third molar extraction. CGF is recommended during the third molar extraction due to its good biological effects, low cost and simple preparation procedures.
BACKGROUND: ChiCTR2300077819.
摘要：
目的：本研究的目的是评估浓缩生长因子（CGF）在预防阻生第三磨牙拔除术后并发症中的作用。
方法：共有25名双侧对称第三磨牙受累（50个拔牙部位）的健康患者入组，随机化，双盲临床试验。在同一预约下在下颌骨的两个部位进行第三磨牙拔除。使用抛硬币进行随机化以选择测试和对照位点。将CGF放置在拔牙槽中，并将该槽缝合（试验组），而仅缝合对侧窝（对照组）。每个病人都作为自己的控制。主要结果是通过视觉模拟量表（VAS）评估疼痛和1日的面部肿胀，术后第3天和第7天。次要结果是拔牙后立即以及第3个月和第6个月通过锥形束计算机断层扫描（CBCT）评估牙槽骨高度（ABH）和牙槽骨密度（ABD）在拔牙槽中的骨愈合。
结果：25名患者（12名女性，13名男性；平均年龄29.17），双侧第三磨牙受累。与对照部位相比，CGF部位在术后第3天和第7天的疼痛显着减轻，而在术后第1天（第3天，p=0.009；第7天，p=0.039)。试验组和对照组在不同时间间隔的面部肿胀和骨愈合方面差异无统计学意义,尽管获得的数据稍微有利于CGF组(p>0.05)。没有出现感染等严重不良反应,肺泡炎,感觉异常,在所有病例的随访期间骨折。
结论：本研究证明了CGF对缓解第三磨牙拔除后疼痛严重程度的作用。
结论：在拔牙槽中放置CGF可以减轻第三磨牙拔除后的术后疼痛并减轻患者的不适。CGF由于其良好的生物学效应而被推荐在第三磨牙提取过程中，成本低，制备程序简单。
背景：ChiCTR2300077819.
方法：共有25名双侧对称第三磨牙受累（50个拔牙部位）的健康患者入组，随机化，双盲临床试验。在同一预约下在下颌骨的两个部位进行第三磨牙拔除。使用抛硬币进行随机化以选择测试和对照位点。将CGF放置在拔牙槽中，并将该槽缝合（试验组），而仅缝合对侧窝（对照组）。每个病人都作为自己的控制。主要结果是通过视觉模拟量表（VAS）评估疼痛和1日的面部肿胀，术后第3天和第7天。次要结果是拔牙后立即以及第3个月和第6个月通过锥形束计算机断层扫描（CBCT）评估牙槽骨高度（ABH）和牙槽骨密度（ABD）在拔牙槽中的骨愈合。
结果：25名患者（12名女性，13名男性；平均年龄29.17），双侧第三磨牙受累。与对照部位相比，CGF部位在术后第3天和第7天的疼痛显着减轻，而在术后第1天（第3天，p=0.009；第7天，p=0.039)。试验组和对照组在不同时间间隔的面部肿胀和骨愈合方面差异无统计学意义,尽管获得的数据稍微有利于CGF组(p>0.05)。没有出现感染等严重不良反应,肺泡炎,感觉异常,在所有病例的随访期间骨折。
结论：本研究证明了CGF对缓解第三磨牙拔除后疼痛严重程度的作用。
结论：在拔牙槽中放置CGF可以减轻第三磨牙拔除后的术后疼痛并减轻患者的不适。CGF由于其良好的生物学效应而被推荐在第三磨牙提取过程中，成本低，制备程序简单。
背景：ChiCTR2300077819.
