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Abstract：
OBJECTIVE: Patients with chronic pain disorders, including Temporomandibular Disorders (TMDs) endorse high levels of sleep disturbances, frequently reporting reduced sleep quality. Despite this, little is known about the effect that daytime pain has on the microstructure and macro-architecture of sleep. Therefore, we aimed to examine the extent to which daytime pain sensitivity, measured using quantitative sensory testing (QST), is associated with objective sleep parameters the following night, including sleep architecture and power spectral density, in women with TMD.
METHODS: 144 females with myalgia and arthralgia by examination using the Diagnostic criteria for TMD completed a comprehensive QST battery consisting of General Pain Sensitivity, Central Sensitization Index, and Masseter Pressure Pain Threshold assessments. Polysomnography was collected the same night to measure sleep architecture and calculate relative power in delta, theta, alpha, sigma, and beta power bands.
RESULTS: Central Sensitization (B = -3.069, P = .009), General Pain Sensitivity Indices (B = -3.069, P = .007), and Masseter Pain Pressure Threshold (B = 0.030, P = .008) were significantly associated with lower REM% both before and after controlling for covariates. Pain sensitivity measures were not significantly associated with relative power in any of the spectral bands nor with any other sleep architectural stages.
CONCLUSIONS: Our findings demonstrate that higher generalized pain sensitivity, masseter pain pressure threshold, as well as central sensitization were associated with a lower percentage of REM in participants with myofascial pain and arthralgia of the masticatory system. These findings provide an important step toward understanding the mechanistic underpinnings of how chronic pain interacts with sleep physiology.
METHODS: 144 females with myalgia and arthralgia by examination using the Diagnostic criteria for TMD completed a comprehensive QST battery consisting of General Pain Sensitivity, Central Sensitization Index, and Masseter Pressure Pain Threshold assessments. Polysomnography was collected the same night to measure sleep architecture and calculate relative power in delta, theta, alpha, sigma, and beta power bands.
RESULTS: Central Sensitization (B = -3.069, P = .009), General Pain Sensitivity Indices (B = -3.069, P = .007), and Masseter Pain Pressure Threshold (B = 0.030, P = .008) were significantly associated with lower REM% both before and after controlling for covariates. Pain sensitivity measures were not significantly associated with relative power in any of the spectral bands nor with any other sleep architectural stages.
CONCLUSIONS: Our findings demonstrate that higher generalized pain sensitivity, masseter pain pressure threshold, as well as central sensitization were associated with a lower percentage of REM in participants with myofascial pain and arthralgia of the masticatory system. These findings provide an important step toward understanding the mechanistic underpinnings of how chronic pain interacts with sleep physiology.
摘要：
目的：慢性疼痛障碍患者，包括颞下颌关节紊乱病（TMD）支持高水平的睡眠障碍，经常报告睡眠质量下降。尽管如此,人们对白天疼痛对睡眠的微观结构和宏观结构的影响知之甚少。因此,我们的目的是检查白天疼痛敏感性的程度，使用定量感官测试(QST)测量，与第二天晚上的客观睡眠参数相关联，包括睡眠结构和功率谱密度，患有TMD的女性。
方法：：144名患有肌痛和关节痛的女性通过TMD诊断标准检查完成了全面的QST系列，包括一般疼痛敏感性，中央敏感化指数，和咬肌压力疼痛阈值评估。多导睡眠图（PSG）是在同一晚上收集的，以测量睡眠结构和计算相对功率的增量，theta,阿尔法，sigma,和β功率带。
结果：中央敏化（B=-3.069，P=0.009），一般疼痛敏感性指数（B=-3.069，P=0.007），在控制协变量之前和之后，咬肌疼痛压力阈值（B=0.030，P=0.008）与较低的REM％显着相关。疼痛敏感度测量值与任何光谱带中的相对功率均无显著相关，也没有任何其他睡眠建筑阶段。
结论：我们的研究结果表明，较高的全身疼痛敏感性，咬肌疼痛压力阈值，在患有咀嚼系统肌筋膜疼痛和关节痛的参与者中,中枢致敏与较低的REM百分比相关.这些发现为理解慢性疼痛如何与睡眠生理学相互作用的机制基础提供了重要的一步。
方法：：144名患有肌痛和关节痛的女性通过TMD诊断标准检查完成了全面的QST系列，包括一般疼痛敏感性，中央敏感化指数，和咬肌压力疼痛阈值评估。多导睡眠图（PSG）是在同一晚上收集的，以测量睡眠结构和计算相对功率的增量，theta,阿尔法，sigma,和β功率带。
结果：中央敏化（B=-3.069，P=0.009），一般疼痛敏感性指数（B=-3.069，P=0.007），在控制协变量之前和之后，咬肌疼痛压力阈值（B=0.030，P=0.008）与较低的REM％显着相关。疼痛敏感度测量值与任何光谱带中的相对功率均无显著相关，也没有任何其他睡眠建筑阶段。
结论：我们的研究结果表明，较高的全身疼痛敏感性，咬肌疼痛压力阈值，在患有咀嚼系统肌筋膜疼痛和关节痛的参与者中,中枢致敏与较低的REM百分比相关.这些发现为理解慢性疼痛如何与睡眠生理学相互作用的机制基础提供了重要的一步。
