Abstract：
The lack of in vivo studies on the delivery of doxorubicin within human skin, especially the absence of data on the doxorubicin diffusion coefficient, has made understanding its transdermal delivery kinetics challenging. In this study, as a first step, governing equations and finite element methods were employed to reproduce Franz diffusion cell experiment in human cadaver skin. The application of this experiment representative model with a fitting method resulted in approximate values for the diffusivity of doxorubicin across various skin layers. The estimated values were used later to conduct a comprehensive examination of doxorubicin administration for breast tumor treatments. In a 2D axisymmetric model using Fick\'s Law and then a microneedles array 3D model, crucial parameters effects on delivery efficiency were examined, such as the microneedle tip diameter, tip-to-tip distance, and tumor depth. As highlighted by the findings of this study, these parameters have an impact on the effectiveness of doxorubicin delivery for treating breast tumors. The focus of this research is on the potential of numerical methods in biomedical engineering, which addresses the urgent need for data on doxorubicin diffusion in human skin and offers valuable insights into optimizing drug delivery strategies for enhanced therapeutic outcomes.
摘要：
缺乏对阿霉素在人皮肤内递送的体内研究，特别是缺乏阿霉素扩散系数的数据，对其透皮给药动力学的理解具有挑战性。在这项研究中,作为第一步,采用控制方程和有限元方法在人体尸体皮肤中复制了Franz扩散细胞实验。该实验代表性模型与拟合方法的应用导致阿霉素在各个皮肤层中的扩散率的近似值。稍后将估计值用于对乳腺肿瘤治疗的阿霉素给药进行全面检查。在使用菲克定律和微针阵列3D模型的2D轴对称模型中，检查了关键参数对输送效率的影响，例如微针尖端直径，尖端到尖端的距离，和肿瘤深度。正如这项研究的结果所强调的那样，这些参数对多柔比星给药治疗乳腺肿瘤的有效性有影响.这项研究的重点是生物医学工程中数值方法的潜力，这解决了对阿霉素在人类皮肤中扩散数据的迫切需求，并为优化药物递送策略以提高治疗效果提供了有价值的见解。
