PDF(Pubmed)
Abstract：
Hypoxia-inducible factor-1α (HIF-1α) is a major transcriptional factor, which plays an important role in cellular reprogramming processes under hypoxic conditions, which facilitate solid tumors\' progression. HIF-1α is directly involved in the regulation of the angiogenesis, metabolic reprogramming, and extracellular matrix remodeling of the tumor microenvironment. Therefore, an in-depth study on the role of HIF-1α in solid tumor malignancies is required to develop novel anti-cancer therapeutics. HIF-1α also plays a critical role in regulating growth factors, such as the vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor, in a network manner. Additionally, it plays a significant role in tumor progression and chemotherapy resistance by regulating a variety of angiogenic factors, including angiopoietin 1 and angiopoietin 2, matrix metalloproteinase, and erythropoietin, along with energy pathways. Therefore, this review attempts to provide comprehensive insight into the role of HIF-1α in the energy and angiogenesis pathways of solid tumors.
摘要：
缺氧诱导因子-1α(HIF-1α)是一种主要的转录因子,在缺氧条件下的细胞重编程过程中起着重要作用，促进实体瘤的进展。HIF-1α直接参与血管生成的调节,代谢重编程，和肿瘤微环境的细胞外基质重塑。因此,需要深入研究HIF-1α在实体瘤恶性肿瘤中的作用，以开发新的抗癌疗法。HIF-1α在调节生长因子中也起着关键作用，如血管内皮生长因子，成纤维细胞生长因子,和血小板衍生生长因子，以网络的方式。此外,它通过调节多种血管生成因子在肿瘤进展和化疗耐药中发挥重要作用，包括血管生成素1和血管生成素2，基质金属蛋白酶，和促红细胞生成素,以及能量路径。因此,这篇综述试图为HIF-1α在实体瘤能量和血管生成途径中的作用提供全面的见解。
