hiPSC 心肌细胞缺血和再灌注过程中缺氧和收缩功能障碍机制的计算机模拟研究。
关键词: In silico modeling Action potential Cardiac metabolism Human stem cell-derived cardiomyocytes Ischemia Levosimendan Pharmacology Reperfusion
Mesh : Humans Myocytes, Cardiac / metabolism pathology drug effects Induced Pluripotent Stem Cells / metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism Computer Simulation Simendan / pharmacology therapeutic use Myocardial Contraction / drug effects Calcium / metabolism Cell Hypoxia / drug effects Oxygen / metabolism Myocardial Reperfusion Injury / pathology metabolism Animals Models, Biological
来 源:
DOI:10.1242/dmm.050365
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