H3K4me1 促进胚胎干细胞分化过程中的启动子 - 增强子相互作用和基因激活。
关键词: H3K4me1 KMT2B KMT2C/D MLL2 MLL3/4 chromatin contacts differentiation enhancer gene regulation histone methyltransferases
Mesh : Animals Mice Promoter Regions, Genetic Enhancer Elements, Genetic Histones / metabolism genetics Histone-Lysine N-Methyltransferase / genetics metabolism Mouse Embryonic Stem Cells / metabolism cytology Cell Differentiation Transcriptional Activation Methylation Gene Expression Regulation, Developmental Myeloid-Lymphoid Leukemia Protein / metabolism genetics DNA-Binding Proteins / metabolism genetics Lysine / analogs & derivatives
来 源:
DOI:10.1016/j.molcel.2024.02.030
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