Abstract：
The facile fabrication is reported of highly electrochemically active Ti3C2Tx MXene/MWCNT (3D/1D)-modified screen-printed carbon electrode (SPE) for the efficient simultaneous electrochemical detection of paracetamol, theophylline, and caffeine in human blood samples. 3D/1D Ti3C2Tx MXene/MWCNT nanocomposite was synthesized using microwave irradiation and ultrasonication processes. Then, the Ti3C2Tx/MWCNT-modified SPE electrode was fabricated and thoroughly characterized towards its physicochemical and electrochemical properties using XPS, TEM, FESEM, XRD, electrochemical impedance spectroscopy, cyclic voltammetry, and differential pulse voltammetry techniques. As-constructed Ti3C2Tx-MWCNT/SPE offers excellent electrochemical sensing performance with good detection limits (0.23, 0.57, and 0.43 µM) and wide linear ranges (1.0 ~ 90.1, 2.0 ~ 62.0, and 2.0-90.9 µM) for paracetamol, caffeine, and theophylline, respectively, in the human samples. Notably, the non-enzymatic electroactive nanocomposite-modified electrode has depicted a semicircle Nyquist plot with low charge transfer resistance (Rct∼95 Ω), leading to high ionic diffusion and facilitating an excellent electron transfer path. All the above results in efficient stability, reproducibility, repeatability, and sensitivity compared with other reported works, and thus, it claims its practical utilization in realistic clinical applications.
摘要：
据报道，高度电化学活性的Ti3C2TxMXene/MWCNT（3D/1D）修饰的丝网印刷碳电极（SPE）易于制造，可有效地同时电化学检测扑热息痛，茶碱,和人体血液样本中的咖啡因.使用微波辐射和超声过程合成了3D/1DTi3C2TxMXene/MWCNT纳米复合材料。然后，制备了Ti3C2Tx/MWCNT修饰的SPE电极，并使用XPS对其物理化学和电化学性质进行了全面表征，TEM,FESEM，XRD,电化学阻抗谱，循环伏安法,和差分脉冲伏安技术。构造的Ti3C2Tx-MWCNT/SPE具有优异的电化学传感性能，具有良好的检测限（0.23、0.57和0.43µM）和对乙酰氨基酚的宽线性范围（1.0〜90.1、2.0〜62.0和2.0-90.9µM），咖啡因,和茶碱,分别,在人类样本中。值得注意的是,非酶电活性纳米复合材料修饰电极描绘了一个半圆奈奎斯特图，具有低电荷转移电阻(Rct~95Ω)，导致高离子扩散和促进优良的电子转移路径。所有上述结果的有效稳定性，再现性，重复性,与其他报道的作品相比，灵敏度，因此，它声称其在实际临床应用中的实际应用。
