PDF(Pubmed)
Abstract：
UNASSIGNED: Maxillary ameloblastoma is a rare, slow-growing odontogenic tumor that can recur after surgical excision, be locally aggressive, and rarely develop systemic metastases. We describe the course and management of a patient with recurrent maxillary ameloblastoma with orbital invasion and systemic metastases, the fourth case of its kind to be described in the literature.
UNASSIGNED: A 50-year-old female presented with left hyperglobus. A diagnosis of maxillary ameloblastoma was made based on biopsy and neuroimaging with MRI and CT. Surgical management included partial maxillectomy with orbital floor reconstruction, given the orbital invasion. Three years later, left hyperglobus recurred, and the patient was found to have orbital recurrence and lung metastases on PET imaging. The lung and orbital lesions have responded well to chemoradiation therapy without surgical intervention.
UNASSIGNED: Maxillary ameloblastoma is a rare tumor that typically arises from odontogenic tissues. Though considered benign, they can recur and in the case of our patient, metastasize. Complete surgical excision with wide surgical margins is associated with a shorter average time to recurrence and a lower incidence of metastasis. Cases of metastasis are managed with chemotherapy with or without adjuvant radiotherapy. Precision medicine may play a role in managing this entity in the future, given the discovery of differing profiles of maxillary ameloblastoma compared to mandibular. Ophthalmologists should be aware of this tumor as it can invade the orbit, resulting in significant ocular morbidity and mortality.
UNASSIGNED: A 50-year-old female presented with left hyperglobus. A diagnosis of maxillary ameloblastoma was made based on biopsy and neuroimaging with MRI and CT. Surgical management included partial maxillectomy with orbital floor reconstruction, given the orbital invasion. Three years later, left hyperglobus recurred, and the patient was found to have orbital recurrence and lung metastases on PET imaging. The lung and orbital lesions have responded well to chemoradiation therapy without surgical intervention.
UNASSIGNED: Maxillary ameloblastoma is a rare tumor that typically arises from odontogenic tissues. Though considered benign, they can recur and in the case of our patient, metastasize. Complete surgical excision with wide surgical margins is associated with a shorter average time to recurrence and a lower incidence of metastasis. Cases of metastasis are managed with chemotherapy with or without adjuvant radiotherapy. Precision medicine may play a role in managing this entity in the future, given the discovery of differing profiles of maxillary ameloblastoma compared to mandibular. Ophthalmologists should be aware of this tumor as it can invade the orbit, resulting in significant ocular morbidity and mortality.
摘要：
■上颌成釉细胞瘤是一种罕见的，生长缓慢的牙源性肿瘤，可在手术切除后复发，在当地具有侵略性，很少发生全身转移。我们描述了复发性上颌骨成釉细胞瘤伴眼眶浸润和全身转移的患者的病程和治疗，这是在文献中描述的第四种情况。
■一名50岁的女性出现左眼球。根据活检和MRI和CT的神经影像学诊断上颌成釉细胞瘤。手术治疗包括上颌骨部分切除术和眶底重建，鉴于轨道入侵。三年后,左眼球复发，PET成像发现患者有眼眶复发和肺转移。在没有手术干预的情况下，肺和眼眶病变对放化疗反应良好。
■上颌成釉细胞瘤是一种罕见的肿瘤，通常来自牙源性组织。虽然被认为是良性的，它们可以复发，就我们的病人而言，转移。手术切缘宽的完整手术切除与平均复发时间短和转移发生率低相关。转移病例可通过有或没有辅助放射疗法的化学疗法进行处理。精准医疗可能会在未来管理这个实体方面发挥作用，考虑到与下颌骨相比，上颌成釉细胞瘤的轮廓不同。眼科医生应该意识到这种肿瘤可以侵入眼眶，导致显著的眼部发病率和死亡率。
■一名50岁的女性出现左眼球。根据活检和MRI和CT的神经影像学诊断上颌成釉细胞瘤。手术治疗包括上颌骨部分切除术和眶底重建，鉴于轨道入侵。三年后,左眼球复发，PET成像发现患者有眼眶复发和肺转移。在没有手术干预的情况下，肺和眼眶病变对放化疗反应良好。
■上颌成釉细胞瘤是一种罕见的肿瘤，通常来自牙源性组织。虽然被认为是良性的，它们可以复发，就我们的病人而言，转移。手术切缘宽的完整手术切除与平均复发时间短和转移发生率低相关。转移病例可通过有或没有辅助放射疗法的化学疗法进行处理。精准医疗可能会在未来管理这个实体方面发挥作用，考虑到与下颌骨相比，上颌成釉细胞瘤的轮廓不同。眼科医生应该意识到这种肿瘤可以侵入眼眶，导致显著的眼部发病率和死亡率。
