Abstract：
BACKGROUND: Thiazolidine-2,4-dione (2,4-TZD) is a flexible pharmacophore and a privileged platform and contains a five-membered ring with a 2-oxygen atom with double bond 2,4- position and one nitrogen atom as well as sulphur containing in the heterocyclic compound. A famous electron-rich nitrogen transporter combines invigorating electronic properties with the prospective for elemental applications. Thiazolidine-2,4-dione analogues have been synthesized using a variety of methods, all of which have shown to have a strong biological effect.
OBJECTIVE: The study of the biological activity of Thiazolidine-2,4-dione derivatives has been a fascinating field of pharmaceutical chemistry and has many purposes. This derivative described in the literature between 1995 to 2023 was the focus of this study. Thiazolidine-2,4-diones have been discussed in terms of their introduction, general method, synthetic scheme and antidiabetic significance in the current review.
CONCLUSIONS: Thiazolidine-2,4-diones are well-known heterocyclic compounds. The synthesis of Thiazolidine-2,4-diones has been described using a variety of methods. Antidiabetic activity has been discovered in several Thiazolidine-2,4-dione derivatives, which enhance further research. The use of Thiazolidine-2,4-diones to treat antidiabetics has piqued researchers\' interest in learning more about thiazolidine-2,4-diones.
OBJECTIVE: The study of the biological activity of Thiazolidine-2,4-dione derivatives has been a fascinating field of pharmaceutical chemistry and has many purposes. This derivative described in the literature between 1995 to 2023 was the focus of this study. Thiazolidine-2,4-diones have been discussed in terms of their introduction, general method, synthetic scheme and antidiabetic significance in the current review.
CONCLUSIONS: Thiazolidine-2,4-diones are well-known heterocyclic compounds. The synthesis of Thiazolidine-2,4-diones has been described using a variety of methods. Antidiabetic activity has been discovered in several Thiazolidine-2,4-dione derivatives, which enhance further research. The use of Thiazolidine-2,4-diones to treat antidiabetics has piqued researchers\' interest in learning more about thiazolidine-2,4-diones.
摘要：
背景:噻唑烷-2,4-二酮(2,4-TZD)是一种灵活的药效团和特权平台,并且在杂环化合物中含有具有带双键2,4-位的2-氧原子和一个氮原子的五元环以及含硫。著名的富电子氮转运蛋白将令人振奋的电子特性与元素应用的前景相结合。噻唑烷-2,4-二酮类似物已使用多种方法合成，所有这些都显示出强大的生物学效应。
目的：噻唑烷-2,4-二酮衍生物的生物活性研究一直是药物化学的迷人领域，具有许多目的。1995年至2023年文献中描述的这种衍生物是本研究的重点。已经讨论了噻唑烷-2,4-二酮的介绍，一般方法,本综述中的合成方案和抗糖尿病意义。
结论:噻唑烷-2,4-二酮是众所周知的杂环化合物。已经使用多种方法描述了噻唑烷-2,4-二酮的合成。已经在几种噻唑烷-2,4-二酮衍生物中发现了抗糖尿病活性，这加强了进一步的研究。使用噻唑烷-2,4-二酮治疗抗糖尿病药引起了研究人员对了解更多关于噻唑烷-2,4-二酮的兴趣。
目的：噻唑烷-2,4-二酮衍生物的生物活性研究一直是药物化学的迷人领域，具有许多目的。1995年至2023年文献中描述的这种衍生物是本研究的重点。已经讨论了噻唑烷-2,4-二酮的介绍，一般方法,本综述中的合成方案和抗糖尿病意义。
结论:噻唑烷-2,4-二酮是众所周知的杂环化合物。已经使用多种方法描述了噻唑烷-2,4-二酮的合成。已经在几种噻唑烷-2,4-二酮衍生物中发现了抗糖尿病活性，这加强了进一步的研究。使用噻唑烷-2,4-二酮治疗抗糖尿病药引起了研究人员对了解更多关于噻唑烷-2,4-二酮的兴趣。
