PDF(Pubmed)
Abstract：
UNASSIGNED: While statin therapy is the preferred treatment for hyperlipidemia, literature supports the low-density lipoprotein (LDL) lowering effects associated with red yeast rice, berberine, and Silybum marianum. Dietary supplements may be perceived as a more affordable alternative to prescription medication.
UNASSIGNED: We determined cost-effectiveness of generic pravastatin versus single-ingredient dietary supplements in relation to LDL lowering effect.
UNASSIGNED: Data from meta-analyses and systematic reviews was extracted to calculate pooled weighted mean LDL differences amongst generic pravastatin and single ingredient dietary supplements. The effect was then divided by average 30-day costs and compared amongst agents.
UNASSIGNED: The greatest difference was seen in pravastatin 40 mg [MD -57.88 mg/dL (95%CI: - 64.80 to -50.96)], followed by pravastatin 10 mg [MD -41.30 mg/dL (95%CI: 63.30 to - 19.40)], red yeast rice [MD -25.39 (95%CI: -32.98 to -17.81)], berberine [MD -15.13 (95%CI: -21.78 to -8.48)], and Silybum marianum [MD -9.51 mg/dL (95%CI: -22.13 to - 0.10)]. were divided by mean difference to calculate cost per mg/dL reduction in LDL. Cost-effectiveness was greatest for pravastatin 10 mg [$0.66/mg/dL LDL reduction (range: $0.39 to $1.13)], followed by pravastatin 40 mg [$0.74/mg/dL LDL reduction (range: $0.66 to $0.84)], berberine [$0.81/mg/dL LDL reduction (range: $0.56 to $1.44)], red yeast rice [$0.84/mg/dL reduction (range: $0.67 to $1.13)], and Silybum marianum [$0.88/mg/dL LDL reduction (range: $0.38 to $82.02)].
UNASSIGNED: Pravastatin is most cost-effective in each scenario whether or not prescription insurance is utilized.
UNASSIGNED: We determined cost-effectiveness of generic pravastatin versus single-ingredient dietary supplements in relation to LDL lowering effect.
UNASSIGNED: Data from meta-analyses and systematic reviews was extracted to calculate pooled weighted mean LDL differences amongst generic pravastatin and single ingredient dietary supplements. The effect was then divided by average 30-day costs and compared amongst agents.
UNASSIGNED: The greatest difference was seen in pravastatin 40 mg [MD -57.88 mg/dL (95%CI: - 64.80 to -50.96)], followed by pravastatin 10 mg [MD -41.30 mg/dL (95%CI: 63.30 to - 19.40)], red yeast rice [MD -25.39 (95%CI: -32.98 to -17.81)], berberine [MD -15.13 (95%CI: -21.78 to -8.48)], and Silybum marianum [MD -9.51 mg/dL (95%CI: -22.13 to - 0.10)]. were divided by mean difference to calculate cost per mg/dL reduction in LDL. Cost-effectiveness was greatest for pravastatin 10 mg [$0.66/mg/dL LDL reduction (range: $0.39 to $1.13)], followed by pravastatin 40 mg [$0.74/mg/dL LDL reduction (range: $0.66 to $0.84)], berberine [$0.81/mg/dL LDL reduction (range: $0.56 to $1.44)], red yeast rice [$0.84/mg/dL reduction (range: $0.67 to $1.13)], and Silybum marianum [$0.88/mg/dL LDL reduction (range: $0.38 to $82.02)].
UNASSIGNED: Pravastatin is most cost-effective in each scenario whether or not prescription insurance is utilized.
摘要：
■虽然他汀类药物治疗是高脂血症的首选治疗方法，文献支持与红曲米相关的低密度脂蛋白（LDL）降低作用，小檗碱,和水飞蓟草.膳食补充剂可能被认为是处方药的更实惠的替代品。
我们确定了普伐他汀与单一成分膳食补充剂在降低LDL作用方面的成本效益。
■从荟萃分析和系统评价中提取数据，以计算普伐他汀和单一成分膳食补充剂之间的合并加权平均LDL差异。然后将效果除以30天的平均成本，并在代理商之间进行比较。
■在普伐他汀40mg[MD-57.88mg/dL（95CI：-64.80至-50.96）]中观察到最大差异，其次是普伐他汀10mg[MD-41.30mg/dL（95CI：63.30至-19.40）]，红曲米[MD-25.39（95CI：-32.98至-17.81）]，小檗碱[MD-15.13（95CI：-21.78至-8.48）]，和水飞蓟草[MD-9.51mg/dL（95CI：-22.13至-0.10）]。除以平均差，以计算LDL每mg/dL降低的成本。普伐他汀10mg的成本效益最高[LDL降低0.66美元/mg/dL（范围：0.39美元至1.13美元）]，其次是普伐他汀40mg[LDL降低0.74美元/mg/dL（范围：0.66美元至0.84美元）]，小檗碱[$0.81/mg/dLLDL降低（范围：$0.56至$1.44）]，红曲米[减少0.84美元/毫克/分升（范围：0.67美元至1.13美元）]，和水飞蓟草[$0.88/mg/dLLDL降低（范围：$0.38至$82.02）]。
■无论是否使用处方保险，普伐他汀在每种情况下都是最具成本效益的。
我们确定了普伐他汀与单一成分膳食补充剂在降低LDL作用方面的成本效益。
■从荟萃分析和系统评价中提取数据，以计算普伐他汀和单一成分膳食补充剂之间的合并加权平均LDL差异。然后将效果除以30天的平均成本，并在代理商之间进行比较。
■在普伐他汀40mg[MD-57.88mg/dL（95CI：-64.80至-50.96）]中观察到最大差异，其次是普伐他汀10mg[MD-41.30mg/dL（95CI：63.30至-19.40）]，红曲米[MD-25.39（95CI：-32.98至-17.81）]，小檗碱[MD-15.13（95CI：-21.78至-8.48）]，和水飞蓟草[MD-9.51mg/dL（95CI：-22.13至-0.10）]。除以平均差，以计算LDL每mg/dL降低的成本。普伐他汀10mg的成本效益最高[LDL降低0.66美元/mg/dL（范围：0.39美元至1.13美元）]，其次是普伐他汀40mg[LDL降低0.74美元/mg/dL（范围：0.66美元至0.84美元）]，小檗碱[$0.81/mg/dLLDL降低（范围：$0.56至$1.44）]，红曲米[减少0.84美元/毫克/分升（范围：0.67美元至1.13美元）]，和水飞蓟草[$0.88/mg/dLLDL降低（范围：$0.38至$82.02）]。
■无论是否使用处方保险，普伐他汀在每种情况下都是最具成本效益的。
