{Reference Type}: Journal Article
{Title}: Cost-effectiveness of dietary supplement ingredients versus generic statins for LDL reduction.
{Author}: White CM;Sedensky A;Sicignano D;Galli KJ;
{Journal}: Explor Res Clin Soc Pharm
{Volume}: 13
{Issue}: 0
{Year}: 2024 Mar
暂无{DOI}: 10.1016/j.rcsop.2024.100428
{Abstract}: <B>UNASSIGNED: </B>While statin therapy is the preferred treatment for hyperlipidemia, literature supports the low-density lipoprotein (LDL) lowering effects associated with red yeast rice, berberine, and Silybum marianum. Dietary supplements may be perceived as a more affordable alternative to prescription medication.<BR><B>UNASSIGNED: </B>We determined cost-effectiveness of generic pravastatin versus single-ingredient dietary supplements in relation to LDL lowering effect.<BR><B>UNASSIGNED: </B>Data from meta-analyses and systematic reviews was extracted to calculate pooled weighted mean LDL differences amongst generic pravastatin and single ingredient dietary supplements. The effect was then divided by average 30-day costs and compared amongst agents.<BR><B>UNASSIGNED: </B>The greatest difference was seen in pravastatin 40 mg [MD -57.88 mg/dL (95%CI: - 64.80 to -50.96)], followed by pravastatin 10 mg [MD -41.30 mg/dL (95%CI: 63.30 to - 19.40)], red yeast rice [MD -25.39 (95%CI: -32.98 to -17.81)], berberine [MD -15.13 (95%CI: -21.78 to -8.48)], and Silybum marianum [MD -9.51 mg/dL (95%CI: -22.13 to - 0.10)]. were divided by mean difference to calculate cost per mg/dL reduction in LDL. Cost-effectiveness was greatest for pravastatin 10 mg [$0.66/mg/dL LDL reduction (range: $0.39 to $1.13)], followed by pravastatin 40 mg [$0.74/mg/dL LDL reduction (range: $0.66 to $0.84)], berberine [$0.81/mg/dL LDL reduction (range: $0.56 to $1.44)], red yeast rice [$0.84/mg/dL reduction (range: $0.67 to $1.13)], and Silybum marianum [$0.88/mg/dL LDL reduction (range: $0.38 to $82.02)].<BR><B>UNASSIGNED: </B>Pravastatin is most cost-effective in each scenario whether or not prescription insurance is utilized.