Abstract：
Magnusiomyces capitatus (M. capitatus) is an emerging opportunistic yeast, rarely found as a causal agent of invasive fungal infection. In this study, we report a 31-year-old man infected with M. capitatus in the oral cavity, with a history of heroin and amphetamine abuse. M. capitatus was isolated through culture and microscopic analysis and identified by PCR amplification of the ITS DNA region. Based on the in vitro antifungal susceptibility test, the lowest MICs for M. capitatus were recorded for nystatin, itraconazole, and amphotericin, while higher MICs were observed for caspofungin and fluconazole. Treatment with nystatin successfully eliminated M. capitatus and relieved the clinical symptoms. This study presents the first case of M. capitatus in a patient with substance use disorder, manifesting as a plaque-like ulcer in the oral cavity.
摘要：
capitatusMagnusiomyces(M.capatus)是一种新兴的机会酵母，很少被发现作为侵袭性真菌感染的病原体。在这项研究中,我们报告了一名31岁的男性口腔感染了CapatatusM.有海洛因和安非他明滥用史.通过培养和显微镜分析分离capatusM.，并通过ITSDNA区域的PCR扩增进行鉴定。根据体外抗真菌药敏试验,制霉菌素的最低MIC是记录的，伊曲康唑,和两性霉素,卡泊芬净和氟康唑的MIC较高。制霉菌素治疗成功消除了头孢分枝杆菌，缓解了临床症状。这项研究提出了首例患有药物使用障碍的患者的头孢分枝杆菌，表现为口腔中的斑块样溃疡。
