Abstract：
Chemical labeling methods for proteins are highly researched. Herein, we introduced β-carbonyl sulfonium compounds for selective cysteine modification in proteins within biological systems. Structural tuning led to sulfonium-based probes with high reactivity and selectivity. These probes show excellent biocompatibility, cell uptake, and specificity towards cysteine profiling in live cells.
摘要：
蛋白质的化学标记方法得到了广泛的研究。在这里，我们引入了β-羰基锍化合物，用于生物系统中蛋白质的选择性半胱氨酸修饰。结构调整导致基于锍的探针具有高反应性和选择性。这些探针显示出优异的生物相容性，细胞摄取，以及对活细胞中半胱氨酸分析的特异性。
