{Reference Type}: Journal Article
{Title}: β-Carbonyl sulfonium enables cysteine-specific bioconjugation for activity-based protein profiling in live cells.
{Author}: Wan C;Yang D;Guo X;Zhang T;Ruan Z;Dai C;Xing Y;Yin F;Wang R;Li Z;
{Journal}: Chem Commun (Camb)
{Volume}: 60
{Issue}: 27
{Year}: 2024 Mar 28
{Factor}: 6.065
{DOI}: 10.1039/d4cc00295d
{Abstract}: Chemical labeling methods for proteins are highly researched. Herein, we introduced β-carbonyl sulfonium compounds for selective cysteine modification in proteins within biological systems. Structural tuning led to sulfonium-based probes with high reactivity and selectivity. These probes show excellent biocompatibility, cell uptake, and specificity towards cysteine profiling in live cells.