%0 Journal Article
%T β-Carbonyl sulfonium enables cysteine-specific bioconjugation for activity-based protein profiling in live cells.
%A Wan C
%A Yang D
%A Guo X
%A Zhang T
%A Ruan Z
%A Dai C
%A Xing Y
%A Yin F
%A Wang R
%A Li Z
%J Chem Commun (Camb)
%V 60
%N 27
%D 2024 Mar 28
%M 38482888
%F 6.065
%R 10.1039/d4cc00295d
%X Chemical labeling methods for proteins are highly researched. Herein, we introduced β-carbonyl sulfonium compounds for selective cysteine modification in proteins within biological systems. Structural tuning led to sulfonium-based probes with high reactivity and selectivity. These probes show excellent biocompatibility, cell uptake, and specificity towards cysteine profiling in live cells.