PDF(Pubmed)
Abstract：
OBJECTIVE: The extracellular polysaccharide (EPS) is produced by the bacterium Zoogloea sp. and plays a positive role in tissue repair. The purpose of this study was to clinically and histologically compare the effects of EPS in the healing of traumatic oral ulcers in rats with the effects of triamcinolone.
METHODS: Ulcers were induced in the oral mucous of 45 male Wistar rats, divided into three groups: control group, treated with triamcinolone, and treated with biopolymer gel. In the clinical evaluation, we considered the weight variation of the animals and the size of the lesion area, at baseline and on treatment days 1, 3 and 7. The histological parameters evaluated were the type and intensity of the inflammatory infiltration, the presence of necrosis and foreign body granuloma and the degree of re-epithelialization of the lesion.
RESULTS: The reduction of the lesion area was greater in the animals treated with EPS, with no difference in the intensity of the inflammatory infiltration between the groups on days 3 and 7 of treatment.
CONCLUSIONS: The results suggest that topical application of EPS in traumatic oral ulcers of rats promotes faster repair than triamcinolone ointment, without increasing the intensity of inflammatory infiltration under the lesion.
METHODS: Ulcers were induced in the oral mucous of 45 male Wistar rats, divided into three groups: control group, treated with triamcinolone, and treated with biopolymer gel. In the clinical evaluation, we considered the weight variation of the animals and the size of the lesion area, at baseline and on treatment days 1, 3 and 7. The histological parameters evaluated were the type and intensity of the inflammatory infiltration, the presence of necrosis and foreign body granuloma and the degree of re-epithelialization of the lesion.
RESULTS: The reduction of the lesion area was greater in the animals treated with EPS, with no difference in the intensity of the inflammatory infiltration between the groups on days 3 and 7 of treatment.
CONCLUSIONS: The results suggest that topical application of EPS in traumatic oral ulcers of rats promotes faster repair than triamcinolone ointment, without increasing the intensity of inflammatory infiltration under the lesion.
摘要：
目的：胞外多糖（EPS）由细菌Zoogloeasp。在组织修复中起着积极的作用。本研究的目的是在临床和组织学上比较EPS在大鼠创伤性口腔溃疡愈合中的作用与曲安奈德的作用。
方法：在45只雄性Wistar大鼠的口腔粘膜中诱发溃疡，分为三组:对照组,用曲安奈德治疗,并用生物聚合物凝胶处理。在临床评估中，我们考虑了动物的体重变化和病变区域的大小，在基线和治疗第1、3和7天。评估的组织学参数是炎症浸润的类型和强度，坏死和异物肉芽肿的存在以及病变的再上皮化程度。
结果：在用EPS治疗的动物中，病变面积的减少更大，在治疗的第3天和第7天，各组之间的炎症浸润强度没有差异。
结论：结果表明，外用EPS对大鼠创伤性口腔溃疡的修复速度比曲安奈德软膏快，不增加病变下炎症浸润的强度。
方法：在45只雄性Wistar大鼠的口腔粘膜中诱发溃疡，分为三组:对照组,用曲安奈德治疗,并用生物聚合物凝胶处理。在临床评估中，我们考虑了动物的体重变化和病变区域的大小，在基线和治疗第1、3和7天。评估的组织学参数是炎症浸润的类型和强度，坏死和异物肉芽肿的存在以及病变的再上皮化程度。
结果：在用EPS治疗的动物中，病变面积的减少更大，在治疗的第3天和第7天，各组之间的炎症浸润强度没有差异。
结论：结果表明，外用EPS对大鼠创伤性口腔溃疡的修复速度比曲安奈德软膏快，不增加病变下炎症浸润的强度。
