METHODS: A case-control study was conducted on 17 post-pubertal CAH females and 17 age-matched healthy female controls; the mean age of the patient group was 15.09 ± 3.55 years ranging from 11 to 24 years, while the mean age of the control group was 16.04 ± 3.72 years ranging from 12 to 25 years, the mean post-menarchal age of the patients group was 3.29 ± 1.37 years ranging from 1 to 6 years while the mean post-menarchal age of the control group was 4.13 ± 1.62 years ranging from 1 to 9 years. The degree of hirsutism was compared between the two groups according to the modified Ferriman-Gallwey score, clitoral length was assessed using a digital caliber. Serum levels of adrenal androgens in addition to basal levels of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone, and serum AMH were measured in both groups.
RESULTS: Patients had smaller uterine volumes, and smaller ovarian volumes but a comparable number of antral follicles and comparable serum AMH levels relative to controls.
CONCLUSIONS: Good compliance with treatment in patients with CAH results in good hormonal control, low risk of PCOS, good fertility parameters, and a good ovarian reserve.
目的:通过测量血清AMH水平和超声评估窦卵泡数量来评估月经初潮后诊断为CAH的女性的卵巢储备。
方法:对17名青春期后CAH女性和17名年龄匹配的健康女性对照进行了病例对照研究;患者组的平均年龄为15.09±3.55岁,范围为11至24岁,而对照组的平均年龄为16.04±3.72岁,范围为12至25岁,患者组的平均初潮后年龄为3.29±1.37岁,范围为1至6岁,而对照组的平均初潮后年龄为4.13±1.62岁,范围为1至9岁。根据改良的Ferriman-Gallwey评分比较两组多毛症程度,使用数字口径评估阴蒂长度。除了基础水平的血清卵泡刺激素(FSH),肾上腺雄激素的血清水平,黄体生成素(LH),雌二醇,黄体酮,检测两组血清抗苗勒管激素(AMH)水平。超声评估子宫体积,卵巢体积,和窦卵泡的数量。
结果:患者的子宫体积较小,与对照组相比,卵巢体积较小,但窦卵泡数量相当,血清AMH水平相当。
结论:CAH患者良好的治疗依从性导致激素控制良好,PCOS的低风险,良好的生育参数,和良好的卵巢储备.