PDF(Pubmed)
Abstract：
Diabetes is not only an endocrine but also a vascular disease. Vascular defects are usually seen as consequence of diabetes. However, at the level of the pancreatic islet, vascular alterations have been described before symptom onset. Importantly, the cellular and molecular mechanisms underlying these early vascular defects have not been identified, neither how these could impact the function of islet endocrine cells. In this review, we will discuss the possibility that dysfunction of the mural cells of the microvasculature-known as pericytes-underlies vascular defects observed in islets in pre-symptomatic stages. Pericytes are crucial for vascular homeostasis throughout the body, but their physiological and pathophysiological functions in islets have only recently started to be explored. A previous study had already raised interest in the \"microvascular\" approach to this disease. With our increased understanding of the crucial role of the islet microvasculature for glucose homeostasis, here we will revisit the vascular aspects of islet function and how their deregulation could contribute to diabetes pathogenesis, focusing in particular on type 1 diabetes (T1D).
摘要：
糖尿病不仅是一种内分泌疾病，也是一种血管疾病。血管缺陷通常被视为糖尿病的结果。然而,在胰岛的水平，在症状发作之前已经描述了血管改变。重要的是,这些早期血管缺陷的细胞和分子机制尚未确定，这些都不会影响胰岛内分泌细胞的功能。在这次审查中,我们将讨论微脉管系统的壁细胞-称为周细胞-的功能障碍是在症状前阶段在胰岛中观察到的血管缺陷的基础。周细胞对于整个身体的血管稳态至关重要，但是它们在胰岛中的生理和病理生理功能直到最近才开始被探索。先前的一项研究已经引起了对这种疾病的“微血管”方法的兴趣。随着我们对胰岛微脉管系统对葡萄糖稳态的关键作用的理解，在这里，我们将重新审视胰岛功能的血管方面，以及它们的失调如何导致糖尿病的发病机制，特别关注1型糖尿病（T1D）。
