Abstract：
OBJECTIVE: The aim of this scoping review was to evaluate the available scientific evidence regarding the use of flavonoids in the treatment of caries-affected dentin focusing on bonding to dentin.
METHODS: A comprehensive literature search was performed in five databases from March 2022 and updated in April 2023: PubMed, EMBASE, Scopus, Web of Science, and Scielo. Additionally, the references of included studies were manually searched. Gray literature was excluded from the review.
METHODS: Inclusion criteria included in vitro, in situ, and in vivo studies (animal or human) published in English. Abstracts, reviews, case reports, book chapters, doctoral dissertations, guidelines, and studies using pure plant extracts were excluded. Data collected from the selected studies were summarized and subjected to narrative and descriptive analysis. Out of the 91 studies identified, only 16 studies met the inclusion criteria.
RESULTS: The review analyzed eight different flavonoids (hesperidin, galardin, proanthocyanidin, genipin, quercetin, naringin, epigallocatechin-3-gallate, and other catechins subtypes) used as pretreatment or loaded into adhesive systems, primers, and phosphoric acid. The use of flavonoids improved the mechanical properties of the materials and modified the biological properties of the dentin, reducing collagen loss by the inhibition of proteolytic activity of matrix metalloproteinases (MMPs).
CONCLUSIONS: Based on the findings of this scoping review, it can be concluded that the use of flavonoids as pretreatment or incorporation into dental materials preserves collagen in the hybrid layer, inhibiting the MMPs activities, modifying the collagen fibrils of the dentin matrix and improving the mechanical properties of the dental adhesive systems. Therefore, it represents a promising approach for promoting dentin biomodification. This can result in more stable bonding of adhesive restorations to caries-affected dentin.
METHODS: A comprehensive literature search was performed in five databases from March 2022 and updated in April 2023: PubMed, EMBASE, Scopus, Web of Science, and Scielo. Additionally, the references of included studies were manually searched. Gray literature was excluded from the review.
METHODS: Inclusion criteria included in vitro, in situ, and in vivo studies (animal or human) published in English. Abstracts, reviews, case reports, book chapters, doctoral dissertations, guidelines, and studies using pure plant extracts were excluded. Data collected from the selected studies were summarized and subjected to narrative and descriptive analysis. Out of the 91 studies identified, only 16 studies met the inclusion criteria.
RESULTS: The review analyzed eight different flavonoids (hesperidin, galardin, proanthocyanidin, genipin, quercetin, naringin, epigallocatechin-3-gallate, and other catechins subtypes) used as pretreatment or loaded into adhesive systems, primers, and phosphoric acid. The use of flavonoids improved the mechanical properties of the materials and modified the biological properties of the dentin, reducing collagen loss by the inhibition of proteolytic activity of matrix metalloproteinases (MMPs).
CONCLUSIONS: Based on the findings of this scoping review, it can be concluded that the use of flavonoids as pretreatment or incorporation into dental materials preserves collagen in the hybrid layer, inhibiting the MMPs activities, modifying the collagen fibrils of the dentin matrix and improving the mechanical properties of the dental adhesive systems. Therefore, it represents a promising approach for promoting dentin biomodification. This can result in more stable bonding of adhesive restorations to caries-affected dentin.
摘要：
目的：本范围审查的目的是评估现有的关于使用黄酮类化合物治疗龋齿影响的牙本质的科学证据，重点是与牙本质的结合。
方法：从2022年3月开始在五个数据库中进行了全面的文献检索，并于2023年4月进行了更新：PubMed，EMBASE,Scopus,WebofScience,还有Scielo.此外,纳入研究的参考文献采用人工检索.灰色文献被排除在评论之外。
方法：纳入标准包括体外，在原地,和体内研究（动物或人类）以英文出版。摘要,reviews,病例报告,书籍章节，博士论文,指导方针,使用纯植物提取物的研究被排除在外。从所选研究中收集的数据进行总结，并进行叙述和描述性分析。在确定的91项研究中，只有16项研究符合纳入标准.
结果：该综述分析了八种不同的类黄酮（橙皮苷，galardin,原花青素，京尼平,槲皮素,柚皮苷,表没食子儿茶素-3-没食子酸酯，和其他儿茶素亚型）用作预处理或加载到粘合剂系统中，引物,和磷酸。黄酮类化合物的使用改善了材料的机械性能并改善了牙本质的生物学特性，通过抑制基质金属蛋白酶（MMPs）的蛋白水解活性来减少胶原蛋白的损失。
结论：根据本范围审查的结果，可以得出结论，使用类黄酮作为预处理或掺入牙科材料保留了混合层中的胶原蛋白，抑制MMPs活性，修饰牙本质基质的胶原纤维并改善牙科粘合剂系统的机械性能。因此,它代表了促进牙本质生物修饰的一种有前途的方法。这可以导致粘合剂修复体与受龋齿影响的牙本质的更稳定的粘合。
方法：从2022年3月开始在五个数据库中进行了全面的文献检索，并于2023年4月进行了更新：PubMed，EMBASE,Scopus,WebofScience,还有Scielo.此外,纳入研究的参考文献采用人工检索.灰色文献被排除在评论之外。
方法：纳入标准包括体外，在原地,和体内研究（动物或人类）以英文出版。摘要,reviews,病例报告,书籍章节，博士论文,指导方针,使用纯植物提取物的研究被排除在外。从所选研究中收集的数据进行总结，并进行叙述和描述性分析。在确定的91项研究中，只有16项研究符合纳入标准.
结果：该综述分析了八种不同的类黄酮（橙皮苷，galardin,原花青素，京尼平,槲皮素,柚皮苷,表没食子儿茶素-3-没食子酸酯，和其他儿茶素亚型）用作预处理或加载到粘合剂系统中，引物,和磷酸。黄酮类化合物的使用改善了材料的机械性能并改善了牙本质的生物学特性，通过抑制基质金属蛋白酶（MMPs）的蛋白水解活性来减少胶原蛋白的损失。
结论：根据本范围审查的结果，可以得出结论，使用类黄酮作为预处理或掺入牙科材料保留了混合层中的胶原蛋白，抑制MMPs活性，修饰牙本质基质的胶原纤维并改善牙科粘合剂系统的机械性能。因此,它代表了促进牙本质生物修饰的一种有前途的方法。这可以导致粘合剂修复体与受龋齿影响的牙本质的更稳定的粘合。
