Abstract：
BACKGROUND: Recent studies reported that strict avoidance of milk products in cow\'s milk allergy (CMA) affects growth and bone turnover, causing negative calcium balance and changes in bone metabolism.
OBJECTIVE: To investigate biochemical parameters to predict bone turnover and its relations with height and weight measurements and nutritional intake.
METHODS: Height, weight, and body mass index z scores were plotted for age according to the World Health Organization. A 3-consecutive day food record was analyzed for nutritional values of foods. The blood levels of calcium, phosphorus, alkaline phosphatase, vitamin D, and parathyroid hormone (PTH) were determined.
RESULTS: The study included 69 controls, 66 children with isolated CMA, and 59 children with multiple food allergy (FA). The z scores for weight, height, and body mass index were lower in isolated CMA and multiple FA groups than controls (P < .001, P = .004, and P = .002, respectively). The nutritional intakes of protein, fat, carbohydrates, vitamins B2 and B12, niacin, calcium, and phosphorus were significantly lower in isolated CMA and multiple FA than controls. In infants (≤2 years of age), although blood calcium level was in normal range, it was significantly lower in isolated CMA and multiple FA than in controls (P < .001). In children older than 2 years, PTH level was significantly higher in isolated CMA and multiple FA groups than in controls (P = .003).
CONCLUSIONS: Our study revealed that children with isolated CMA and multiple FA had a high nutrition gap, growth deceleration, and unbalanced bone metabolism, as illustrated by low blood calcium and elevated PTH levels.
OBJECTIVE: To investigate biochemical parameters to predict bone turnover and its relations with height and weight measurements and nutritional intake.
METHODS: Height, weight, and body mass index z scores were plotted for age according to the World Health Organization. A 3-consecutive day food record was analyzed for nutritional values of foods. The blood levels of calcium, phosphorus, alkaline phosphatase, vitamin D, and parathyroid hormone (PTH) were determined.
RESULTS: The study included 69 controls, 66 children with isolated CMA, and 59 children with multiple food allergy (FA). The z scores for weight, height, and body mass index were lower in isolated CMA and multiple FA groups than controls (P < .001, P = .004, and P = .002, respectively). The nutritional intakes of protein, fat, carbohydrates, vitamins B2 and B12, niacin, calcium, and phosphorus were significantly lower in isolated CMA and multiple FA than controls. In infants (≤2 years of age), although blood calcium level was in normal range, it was significantly lower in isolated CMA and multiple FA than in controls (P < .001). In children older than 2 years, PTH level was significantly higher in isolated CMA and multiple FA groups than in controls (P = .003).
CONCLUSIONS: Our study revealed that children with isolated CMA and multiple FA had a high nutrition gap, growth deceleration, and unbalanced bone metabolism, as illustrated by low blood calcium and elevated PTH levels.
摘要：
背景：最近的研究报告说，牛奶过敏（CMA）中严格避免奶制品会影响生长和骨转换，导致钙负平衡和骨代谢的变化。
目的：研究预测骨转换的生化指标及其与身高、体重和营养摄入的关系。
方法：高度，体重,和体重指数（BMI）z得分根据世界卫生组织的年龄绘制。分析了连续3天的食物记录的食物营养价值。钙的血液水平，磷，碱性磷酸酶,维生素D,测定甲状旁腺激素(PTH)。
结果：该研究包括69名对照，59名孤立CMA儿童，和59名患有多种食物过敏(FA)的儿童。体重的z得分，高度,孤立的CMA组和多个FA组的BMI低于对照组（分别为p<0.001，p=0.004，p=0.002）。蛋白质的营养摄入量，脂肪，碳水化合物,维生素B2和B12，烟酸，钙，分离的CMA和多种FA中的磷含量显着低于对照。婴儿（2岁），尽管血钙水平在正常范围内，分离的CMA和多重FA显着低于对照组（p<0.001）。在儿童>2岁，PTH水平在孤立的CMA和多个FA组明显高于对照组(p=0.01)结论:我们的研究表明，儿童与孤立的CMA和多个FA有很高的营养差距,增长减速，和不平衡的骨代谢，如血钙低和PTH水平升高所示。
目的：研究预测骨转换的生化指标及其与身高、体重和营养摄入的关系。
方法：高度，体重,和体重指数（BMI）z得分根据世界卫生组织的年龄绘制。分析了连续3天的食物记录的食物营养价值。钙的血液水平，磷，碱性磷酸酶,维生素D,测定甲状旁腺激素(PTH)。
结果：该研究包括69名对照，59名孤立CMA儿童，和59名患有多种食物过敏(FA)的儿童。体重的z得分，高度,孤立的CMA组和多个FA组的BMI低于对照组（分别为p<0.001，p=0.004，p=0.002）。蛋白质的营养摄入量，脂肪，碳水化合物,维生素B2和B12，烟酸，钙，分离的CMA和多种FA中的磷含量显着低于对照。婴儿（2岁），尽管血钙水平在正常范围内，分离的CMA和多重FA显着低于对照组（p<0.001）。在儿童>2岁，PTH水平在孤立的CMA和多个FA组明显高于对照组(p=0.01)结论:我们的研究表明，儿童与孤立的CMA和多个FA有很高的营养差距,增长减速，和不平衡的骨代谢，如血钙低和PTH水平升高所示。
