Abstract：
Fluoroquinolones (FQs) are a category of broadly used antibiotics. Development of an effective and sensitive approach for determination of trace FQs in environmental and food samples is still challenging. Herein, the hydroxyl-containing triazine-based conjugated microporous polymers (CMPs-OH) was constructed and served as SPE absorbent for the efficient enrichment of FQs. Based on DFT simulations, the excellent enrichment capacity between CMPs-OH and FQs was contributed by hydrogen bonding and π-π interactions. In combination with high-performance liquid chromatography-tandem mass spectrometry, the proposed approach exhibited a wide linear range (0.2-400 ng L-1), low detection limits (0.05-0.15 ng L-1), and good intraday and interday precisions under optimal conditions. In addition, the established method was effectively utilized for the determination of FQs in fourteen samples with recoveries between 82.6 % and 109.2 %. This work provided a feasible sample pretreatment method for monitoring FQs in environmental and food matrices.
摘要：
氟喹诺酮(FQs)是一类广泛使用的抗生素。开发一种有效而灵敏的方法来测定环境和食品样品中的痕量FQ仍然具有挑战性。在这里，构建了含羟基的三嗪基共轭微孔聚合物（CMPs-OH），并将其用作SPE吸收剂，以有效富集FQs。基于DFT模拟，CMPs-OH和FQs之间优异的富集能力是由氢键和π-π相互作用促成的。结合高效液相色谱-串联质谱，所提出的方法表现出很宽的线性范围(0.2-400ngL-1)，低检测限（0.05-0.15ngL-1），以及在最佳条件下良好的日内和日间精确度。此外,该方法有效地用于14份样品中FQs的测定，回收率在82.6％至109.2％之间。这项工作为监测环境和食品基质中的FQ提供了一种可行的样品预处理方法。
