PDF(Pubmed)
Abstract：
UNASSIGNED: To report a case of metastatic uveal melanoma treated with immune checkpoint inhibition in which serial circulating tumor DNA (ctDNA) was assessed throughout treatment.
UNASSIGNED: A 33-year-old man was diagnosed with metastatic uveal melanoma and initially had progression of disease following hepatic embolization and nivolumab/ipilimumab. At the time, plasma ctDNA GNA11 and SF3B1 were measurable and repeat ctDNA showed increased variant allele frequency following further progression of disease on vorinostat. Following additional nivolumab/ipilimumab, radiographic response was noted and repeat ctDNA became undetectable and remained so at 27 months follow up.
UNASSIGNED: Clearance of cell free DNA in metastatic uveal melanoma may be associated with radiographic response to immune checkpoint inhibitors.
UNASSIGNED: A 33-year-old man was diagnosed with metastatic uveal melanoma and initially had progression of disease following hepatic embolization and nivolumab/ipilimumab. At the time, plasma ctDNA GNA11 and SF3B1 were measurable and repeat ctDNA showed increased variant allele frequency following further progression of disease on vorinostat. Following additional nivolumab/ipilimumab, radiographic response was noted and repeat ctDNA became undetectable and remained so at 27 months follow up.
UNASSIGNED: Clearance of cell free DNA in metastatic uveal melanoma may be associated with radiographic response to immune checkpoint inhibitors.
摘要：
报告用免疫检查点抑制治疗的转移性葡萄膜黑素瘤的病例,其中在整个治疗期间评估连续循环肿瘤DNA(ctDNA)。
■一名33岁男子被诊断患有转移性葡萄膜黑色素瘤，最初在肝栓塞和nivolumab/ipilimumab后疾病进展。当时,血浆ctDNAGNA11和SF3B1是可测量的，并且在伏立诺他的疾病进一步进展后，重复的ctDNA显示出增加的变异等位基因频率。在额外的nivolumab/ipilimumab之后，在随访27个月时,我们注意到放射学应答,并且检测不到重复的ctDNA,并且仍然如此.
■转移性葡萄膜黑色素瘤中无细胞DNA的清除可能与放射学对免疫检查点抑制剂的反应有关。
■一名33岁男子被诊断患有转移性葡萄膜黑色素瘤，最初在肝栓塞和nivolumab/ipilimumab后疾病进展。当时,血浆ctDNAGNA11和SF3B1是可测量的，并且在伏立诺他的疾病进一步进展后，重复的ctDNA显示出增加的变异等位基因频率。在额外的nivolumab/ipilimumab之后，在随访27个月时,我们注意到放射学应答,并且检测不到重复的ctDNA,并且仍然如此.
■转移性葡萄膜黑色素瘤中无细胞DNA的清除可能与放射学对免疫检查点抑制剂的反应有关。
