%0 Case Reports
%T Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors.
%A Francis JH
%A Barker CA
%A Canestraro J
%A Abramson DH
%A Shoushtari AN
%J Am J Ophthalmol Case Rep
%V 34
%N 0
%D 2024 Jun
%M 38444640
暂无%R 10.1016/j.ajoc.2024.102021
%X <B>UNASSIGNED: </B>To report a case of metastatic uveal melanoma treated with immune checkpoint inhibition in which serial circulating tumor DNA (ctDNA) was assessed throughout treatment.<BR><B>UNASSIGNED: </B>A 33-year-old man was diagnosed with metastatic uveal melanoma and initially had progression of disease following hepatic embolization and nivolumab/ipilimumab. At the time, plasma ctDNA GNA11 and SF3B1 were measurable and repeat ctDNA showed increased variant allele frequency following further progression of disease on vorinostat. Following additional nivolumab/ipilimumab, radiographic response was noted and repeat ctDNA became undetectable and remained so at 27 months follow up.<BR><B>UNASSIGNED: </B>Clearance of cell free DNA in metastatic uveal melanoma may be associated with radiographic response to immune checkpoint inhibitors.