{Reference Type}: Case Reports
{Title}: Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors.
{Author}: Francis JH;Barker CA;Canestraro J;Abramson DH;Shoushtari AN;
{Journal}: Am J Ophthalmol Case Rep
{Volume}: 34
{Issue}: 0
{Year}: 2024 Jun
暂无{DOI}: 10.1016/j.ajoc.2024.102021
{Abstract}: <B>UNASSIGNED: </B>To report a case of metastatic uveal melanoma treated with immune checkpoint inhibition in which serial circulating tumor DNA (ctDNA) was assessed throughout treatment.<BR><B>UNASSIGNED: </B>A 33-year-old man was diagnosed with metastatic uveal melanoma and initially had progression of disease following hepatic embolization and nivolumab/ipilimumab. At the time, plasma ctDNA GNA11 and SF3B1 were measurable and repeat ctDNA showed increased variant allele frequency following further progression of disease on vorinostat. Following additional nivolumab/ipilimumab, radiographic response was noted and repeat ctDNA became undetectable and remained so at 27 months follow up.<BR><B>UNASSIGNED: </B>Clearance of cell free DNA in metastatic uveal melanoma may be associated with radiographic response to immune checkpoint inhibitors.