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Abstract：
OBJECTIVE: The aim of present study was to evaluate the combined effect of hypertension and activities of daily living (ADL)/instrumental activities of daily living (IADL) with the risk of CVD, stroke and cardiac events.
METHODS: A total of 14,083 participants aged 45 years or older from the China Health and Retirement longitudinal study were included in current study. Participants were divided into 4 groups according to hypertension and ADL/IADL status. Cox proportional hazards regression model was used to explore the associations between hypertension, ADL/IADL and new-onset CVD, stroke and cardiac events.
RESULTS: During the 7-year follow-up, a total of 2,324 respondents experienced CVD (including 783 stroke and 1,740 cardiac events). Individuals with limitations in ADL alone, or with hypertension alone, or with both limitations in ADL and hypertension were associated with increased risk of CVD, with the adjusted hazard ratios (95% confidence intervals) were 1.17(1.00-1.35), 1.36(1.24-1.49) and 1.44(1.23-1.68), respectively. Those with limitations in ADL and hypertension also had higher risk of stroke (hazard ratios = 1.64; 1.26-2.14) and cardiac events (hazard ratios = 1.37; 1.14-1.64). Similarly, individuals with both limitations in IADL and hypertension were associated with increased risk of CVD (hazard ratios = 1.34; 1.15-1.57), stroke (hazard ratios = 1.50; 1.17-1.95) and cardiac events (hazard ratios = 1.27; 1.06-1.53).
CONCLUSIONS: Hypertension and limitations in ADL/IADL jointly increased the risk of CVD, stroke and cardiac events.
METHODS: A total of 14,083 participants aged 45 years or older from the China Health and Retirement longitudinal study were included in current study. Participants were divided into 4 groups according to hypertension and ADL/IADL status. Cox proportional hazards regression model was used to explore the associations between hypertension, ADL/IADL and new-onset CVD, stroke and cardiac events.
RESULTS: During the 7-year follow-up, a total of 2,324 respondents experienced CVD (including 783 stroke and 1,740 cardiac events). Individuals with limitations in ADL alone, or with hypertension alone, or with both limitations in ADL and hypertension were associated with increased risk of CVD, with the adjusted hazard ratios (95% confidence intervals) were 1.17(1.00-1.35), 1.36(1.24-1.49) and 1.44(1.23-1.68), respectively. Those with limitations in ADL and hypertension also had higher risk of stroke (hazard ratios = 1.64; 1.26-2.14) and cardiac events (hazard ratios = 1.37; 1.14-1.64). Similarly, individuals with both limitations in IADL and hypertension were associated with increased risk of CVD (hazard ratios = 1.34; 1.15-1.57), stroke (hazard ratios = 1.50; 1.17-1.95) and cardiac events (hazard ratios = 1.27; 1.06-1.53).
CONCLUSIONS: Hypertension and limitations in ADL/IADL jointly increased the risk of CVD, stroke and cardiac events.
摘要：
目的：本研究的目的是评估高血压和日常生活活动（ADL）/日常生活工具活动（IADL）与CVD风险的联合作用，中风和心脏事件。
方法：本研究纳入了来自中国健康与退休纵向研究的45岁或以上的14,083名参与者。根据高血压和ADL/IADL状态分为4组。Cox比例风险回归模型用于探讨高血压，ADL/IADL和新发CVD，中风和心脏事件。
结果：在7年的随访中，共有2,324名受访者经历了CVD(包括783例卒中和1,740例心脏事件).仅在ADL中有局限性的个人，或者单独有高血压，ADL和高血压与CVD风险增加相关，调整后的风险比（95%置信区间）为1.17（1.00-1.35），1.36（1.24-1.49）和1.44（1.23-1.68），分别。ADL和高血压有局限性的患者也有更高的卒中风险（风险比=1.64;1.26-2.14）和心脏事件（风险比=1.37;1.14-1.64）。同样，同时具有IADL和高血压限制的个体与CVD风险增加相关(风险比=1.34;1.15-1.57),卒中(风险比=1.50;1.17-1.95)和心脏事件(风险比=1.27;1.06-1.53).
结论：高血压和ADL/IADL的局限性共同增加了CVD的风险，中风和心脏事件。
方法：本研究纳入了来自中国健康与退休纵向研究的45岁或以上的14,083名参与者。根据高血压和ADL/IADL状态分为4组。Cox比例风险回归模型用于探讨高血压，ADL/IADL和新发CVD，中风和心脏事件。
结果：在7年的随访中，共有2,324名受访者经历了CVD(包括783例卒中和1,740例心脏事件).仅在ADL中有局限性的个人，或者单独有高血压，ADL和高血压与CVD风险增加相关，调整后的风险比（95%置信区间）为1.17（1.00-1.35），1.36（1.24-1.49）和1.44（1.23-1.68），分别。ADL和高血压有局限性的患者也有更高的卒中风险（风险比=1.64;1.26-2.14）和心脏事件（风险比=1.37;1.14-1.64）。同样，同时具有IADL和高血压限制的个体与CVD风险增加相关(风险比=1.34;1.15-1.57),卒中(风险比=1.50;1.17-1.95)和心脏事件(风险比=1.27;1.06-1.53).
结论：高血压和ADL/IADL的局限性共同增加了CVD的风险，中风和心脏事件。
