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Abstract：
OBJECTIVE: To compare the prognosis of bacteremic pneumonia caused by Klebsiella pneumoniae (K. pneumoniae) and Escherichia coli (E. coli) pathogens.
METHODS: A retrospective analysis was carried out on the clinical data of 162 patients who were diagnosed with bacterial pneumonia caused by either K. pneumoniae or E. coli between 2016-2019. The primary outcome of the analysis was the patients\' 30-day mortality rate.
RESULTS: There were 82 patients in the E. coli bacteremic pneumonia (E. coli-BP) group and 80 patients in the K. pneumoniae bacteremic pneumonia (KP-BP) group. The 30-day mortality rate was 43.75% (n=35/80) in the KP-BP group and 21.95% (n=18/82) in the E. coli-BP group (p<0.001). Following the adjustment for confounding variables in 4 distinct models, the hazard ratios for the primary outcome in KP-BP were determined to be 0.70 (95% confidence interval [CI]: [0.44-1.02]) in Model 1, 0.72 (95% CI: [0.46-1.14]) in Model 2, 0.99 (95% CI: [0.57-1.73]) in Model 3, and 1.22 (95% CI: [0.69-2.18]) in Model 4.
CONCLUSIONS: Patients diagnosed with KP-BP exhibited a similar prognosis as those diagnosed with E. coli-BP. For patients with KP-BP, the risk of mortality was significantly higher for those who were in the intensive care unit, were infected with carbapenem-resistant strains, or had a high sequential organ failure assessment score. In patients with E. coli-BP, the Pitt bacteremia score was strongly associated with the 30-day mortality rate.
METHODS: A retrospective analysis was carried out on the clinical data of 162 patients who were diagnosed with bacterial pneumonia caused by either K. pneumoniae or E. coli between 2016-2019. The primary outcome of the analysis was the patients\' 30-day mortality rate.
RESULTS: There were 82 patients in the E. coli bacteremic pneumonia (E. coli-BP) group and 80 patients in the K. pneumoniae bacteremic pneumonia (KP-BP) group. The 30-day mortality rate was 43.75% (n=35/80) in the KP-BP group and 21.95% (n=18/82) in the E. coli-BP group (p<0.001). Following the adjustment for confounding variables in 4 distinct models, the hazard ratios for the primary outcome in KP-BP were determined to be 0.70 (95% confidence interval [CI]: [0.44-1.02]) in Model 1, 0.72 (95% CI: [0.46-1.14]) in Model 2, 0.99 (95% CI: [0.57-1.73]) in Model 3, and 1.22 (95% CI: [0.69-2.18]) in Model 4.
CONCLUSIONS: Patients diagnosed with KP-BP exhibited a similar prognosis as those diagnosed with E. coli-BP. For patients with KP-BP, the risk of mortality was significantly higher for those who were in the intensive care unit, were infected with carbapenem-resistant strains, or had a high sequential organ failure assessment score. In patients with E. coli-BP, the Pitt bacteremia score was strongly associated with the 30-day mortality rate.
摘要：
目的：比较肺炎克雷伯菌引起的菌血症肺炎的预后（K。肺炎）和大肠杆菌（E.大肠杆菌)病原体。
方法：对2016-2019年162例肺炎克雷伯菌或大肠杆菌所致细菌性肺炎患者的临床资料进行回顾性分析。分析的主要结果是患者30天死亡率。
结果：有82例大肠杆菌细菌性肺炎患者（E.coli-BP)组和肺炎克雷伯菌菌血症肺炎(KP-BP)组80例。KP-BP组30天死亡率为43.75%(n=35/80),大肠杆菌-BP组为21.95%(n=18/82)(p<0.001)。在4个不同模型中对混杂变量进行调整后，KP-BP主要结局的风险比在模型1中为0.70(95%置信区间[CI]:[0.44-1.02]),在模型2中为0.72(95%CI:[0.46-1.14]),在模型3中为0.99(95%CI:[0.57-1.73]),在模型4中为1.22(95%CI:[0.69-2.18]).
结论：诊断为KP-BP的患者表现出与诊断为大肠杆菌-BP的患者相似的预后。对于KP-BP患者，那些在重症监护病房的人的死亡风险明显更高，被耐碳青霉烯菌株感染，或有较高的序贯器官衰竭评估评分。在大肠杆菌-BP患者中，Pitt菌血症评分与30日死亡率密切相关.
方法：对2016-2019年162例肺炎克雷伯菌或大肠杆菌所致细菌性肺炎患者的临床资料进行回顾性分析。分析的主要结果是患者30天死亡率。
结果：有82例大肠杆菌细菌性肺炎患者（E.coli-BP)组和肺炎克雷伯菌菌血症肺炎(KP-BP)组80例。KP-BP组30天死亡率为43.75%(n=35/80),大肠杆菌-BP组为21.95%(n=18/82)(p<0.001)。在4个不同模型中对混杂变量进行调整后，KP-BP主要结局的风险比在模型1中为0.70(95%置信区间[CI]:[0.44-1.02]),在模型2中为0.72(95%CI:[0.46-1.14]),在模型3中为0.99(95%CI:[0.57-1.73]),在模型4中为1.22(95%CI:[0.69-2.18]).
结论：诊断为KP-BP的患者表现出与诊断为大肠杆菌-BP的患者相似的预后。对于KP-BP患者，那些在重症监护病房的人的死亡风险明显更高，被耐碳青霉烯菌株感染，或有较高的序贯器官衰竭评估评分。在大肠杆菌-BP患者中，Pitt菌血症评分与30日死亡率密切相关.
