METHODS: We explore the relationship between BIS and continuous cerebrovascular reactivity in two cohorts: (A) healthy population undergoing elective spinal surgery under general anesthesia, and (B) healthy volunteer cohort of awake controls.
RESULTS: We demonstrate the presence of BISopt in the general anesthesia population (96% of patients), and its absence in awake controls, providing preliminary validation of its existence outside of neural injury populations. Furthermore, we found BIS to be sufficiently separate from overall systemic blood pressure, this indicates that they impact different pathophysiological phenomena to mediate cerebrovascular reactivity.
CONCLUSIONS: Findings here carry implications for the adaptation of the individualized physiologic BISopt concept to non-neural injury populations, both within critical care and the operative theater. However, this work is currently exploratory, and future work is required.
方法:我们在两个队列中探索BIS与连续脑血管反应性之间的关系:(A)在全身麻醉下接受择期脊柱手术的健康人群,和(B)清醒对照的健康志愿者队列。
结果:我们证明了全身麻醉人群(96%的患者)中存在BISopt,以及它在清醒控制中的缺失,在神经损伤人群之外提供其存在的初步验证。此外,我们发现BIS与全身血压完全分离,这表明它们影响不同的病理生理现象来介导脑血管反应性。
结论:研究结果对个性化生理BISopt概念对非神经损伤人群的适应具有重要意义。在重症监护和手术室。然而,这项工作目前是探索性的,需要未来的工作。