PDF(Pubmed)
Abstract：
OBJECTIVE: The use of goal-directed fluid therapy (GDFT) has been shown to reduce complications and improve prognosis in high-risk abdominal surgery patients. However, the utilization of pulse pressure variation (PPV) guided GDFT in laparoscopic surgery remains a subject of debate. We hypothesized that utilizing PPV guidance for GDFT would optimize short-term prognosis in elderly patients undergoing laparoscopic radical resection for colorectal cancer compared to conventional fluid therapy.
METHODS: Elderly patients undergoing laparoscopic radical resection of colorectal cancer were randomized to receive either PPV guided GDFT or conventional fluid therapy and explore whether PPV guided GDFT can optimize the short-term prognosis of elderly patients undergoing laparoscopic radical resection of colorectal cancer compared with conventional fluid therapy.
RESULTS: The incidence of complications was significantly lower in the PPV group compared to the control group (32.8% vs. 57.1%, P = .009). Additionally, the PPV group had a lower occurrence of gastrointestinal dysfunction (19.0% vs. 39.3%, P = .017) and postoperative pneumonia (8.6% vs. 23.2%, P = .033) than the control group.
CONCLUSIONS: Utilizing PPV as a monitoring index for GDFT can improve short-term prognosis in elderly patients undergoing laparoscopic radical resection of colorectal cancer.
BACKGROUND: ChiCTR2300067361; date of registration: January 5, 2023.
METHODS: Elderly patients undergoing laparoscopic radical resection of colorectal cancer were randomized to receive either PPV guided GDFT or conventional fluid therapy and explore whether PPV guided GDFT can optimize the short-term prognosis of elderly patients undergoing laparoscopic radical resection of colorectal cancer compared with conventional fluid therapy.
RESULTS: The incidence of complications was significantly lower in the PPV group compared to the control group (32.8% vs. 57.1%, P = .009). Additionally, the PPV group had a lower occurrence of gastrointestinal dysfunction (19.0% vs. 39.3%, P = .017) and postoperative pneumonia (8.6% vs. 23.2%, P = .033) than the control group.
CONCLUSIONS: Utilizing PPV as a monitoring index for GDFT can improve short-term prognosis in elderly patients undergoing laparoscopic radical resection of colorectal cancer.
BACKGROUND: ChiCTR2300067361; date of registration: January 5, 2023.
摘要：
目的：在高危腹部手术患者中，使用目标导向液体疗法（GDFT）已被证明可以减少并发症并改善预后。然而,脉压变异(PPV)引导下GDFT在腹腔镜手术中的应用仍是一个有争议的话题.我们假设，与常规液体治疗相比，利用PPV指导GDFT可以优化接受腹腔镜结直肠癌根治术的老年患者的短期预后。
方法：将接受腹腔镜结直肠癌根治术的老年患者随机分为PPV引导下的GDFT或常规液体治疗，并探讨与常规液体治疗相比，PPV引导下的GDFT是否能优化接受腹腔镜结直肠癌根治术的老年患者的短期预后。
结果：与对照组相比，PPV组的并发症发生率显着降低（32.8％vs.57.1%,P=.009）。此外,PPV组胃肠功能障碍发生率较低(19.0%vs.39.3%,P=0.017）和术后肺炎（8.6%vs.23.2%,P=0.033）比对照组。
结论：采用PPV作为GDFT的监测指标可改善老年患者腹腔镜结直肠癌根治术的近期预后。
背景：ChiCTR2300067361；注册日期：2023年1月5日。
方法：将接受腹腔镜结直肠癌根治术的老年患者随机分为PPV引导下的GDFT或常规液体治疗，并探讨与常规液体治疗相比，PPV引导下的GDFT是否能优化接受腹腔镜结直肠癌根治术的老年患者的短期预后。
结果：与对照组相比，PPV组的并发症发生率显着降低（32.8％vs.57.1%,P=.009）。此外,PPV组胃肠功能障碍发生率较低(19.0%vs.39.3%,P=0.017）和术后肺炎（8.6%vs.23.2%,P=0.033）比对照组。
结论：采用PPV作为GDFT的监测指标可改善老年患者腹腔镜结直肠癌根治术的近期预后。
背景：ChiCTR2300067361；注册日期：2023年1月5日。
