Abstract：
UNASSIGNED: There is no specificity in the clinical presentation of hemophagocytic lymphohistiocytosis (HLH).
UNASSIGNED: To study some clinical, etiological, and prognostic features of HLH to improve the clinical understanding of the disease.
UNASSIGNED: Retrospective analysis of the clinical data of 125 patients with HLH admitted to our hospital from June 2015 to August 2021, including clinical characteristics, laboratory indicators, and survival period. Statistical analysis was performed from the overall group of study indicators, which included population, children, and adults.
UNASSIGNED: In the whole population, sex, age, blood myoglobin, and NK cell ratio of M-HLH and non-M-HLH patients (P< 0.05), serum albumin, and direct bilirubin were independent correlates of M-HLH. In the pediatric group, age and the proportion of NK cells were significantly different between M-HLH and non-M-HLH patients (P< 0.05). Multivariate Logistic regression analysis showed that all factors were not significantly associated with M-HLH. The associated regression analysis showed that all factors were not significantly associated with M-HLH. ROC curve analysis showed that the best predictive value of NK cell percentage for M-HLH diagnosis in the overall population was 4.96% in the pediatric group and 4.96% in the adult group. The best predictive value for M-HLH diagnosis was 2.08%. The univariate analysis showed that platelet count, alanine aminotransferase, aspartate aminotransferase, serum albumin, direct bilirubin and indirect bilirubin affected prognosis; COX regression showed that none of these factors had a significant relationship. The overall median survival time was 20.7 months in the adult group, 44.3 months in non-M-HLH patients, and 7.73 months in M-HLH patients (p= 0.011); univariate analysis showed that platelet count and serum albumin level affected prognosis; COX regression results in serum albumin level was an independent risk factor for prognosis.
UNASSIGNED: The survival rate of non-M-HLH was significantly better than that of M-HLH; the proportion of NK cells had predictive value for the diagnosis of M-HLH; in the general population, non-M-HLH was more likely to have abnormal liver function than M-HLH: lower platelet count and serum albumin level were associated with poor prognosis, and the lower the platelet count and serum albumin level, the worse the prognosis: in addition, adults with lower serum albumin levels are also associated with poor prognosis.
UNASSIGNED: To study some clinical, etiological, and prognostic features of HLH to improve the clinical understanding of the disease.
UNASSIGNED: Retrospective analysis of the clinical data of 125 patients with HLH admitted to our hospital from June 2015 to August 2021, including clinical characteristics, laboratory indicators, and survival period. Statistical analysis was performed from the overall group of study indicators, which included population, children, and adults.
UNASSIGNED: In the whole population, sex, age, blood myoglobin, and NK cell ratio of M-HLH and non-M-HLH patients (P< 0.05), serum albumin, and direct bilirubin were independent correlates of M-HLH. In the pediatric group, age and the proportion of NK cells were significantly different between M-HLH and non-M-HLH patients (P< 0.05). Multivariate Logistic regression analysis showed that all factors were not significantly associated with M-HLH. The associated regression analysis showed that all factors were not significantly associated with M-HLH. ROC curve analysis showed that the best predictive value of NK cell percentage for M-HLH diagnosis in the overall population was 4.96% in the pediatric group and 4.96% in the adult group. The best predictive value for M-HLH diagnosis was 2.08%. The univariate analysis showed that platelet count, alanine aminotransferase, aspartate aminotransferase, serum albumin, direct bilirubin and indirect bilirubin affected prognosis; COX regression showed that none of these factors had a significant relationship. The overall median survival time was 20.7 months in the adult group, 44.3 months in non-M-HLH patients, and 7.73 months in M-HLH patients (p= 0.011); univariate analysis showed that platelet count and serum albumin level affected prognosis; COX regression results in serum albumin level was an independent risk factor for prognosis.
UNASSIGNED: The survival rate of non-M-HLH was significantly better than that of M-HLH; the proportion of NK cells had predictive value for the diagnosis of M-HLH; in the general population, non-M-HLH was more likely to have abnormal liver function than M-HLH: lower platelet count and serum albumin level were associated with poor prognosis, and the lower the platelet count and serum albumin level, the worse the prognosis: in addition, adults with lower serum albumin levels are also associated with poor prognosis.
摘要：
■噬血细胞性淋巴组织细胞增生症（HLH）的临床表现没有特异性。
■为了研究一些临床，病因学，和HLH的预后特征，以提高临床对疾病的认识。
■回顾性分析2015年6月至2021年8月我院收治的125例HLH患者的临床资料，包括临床特征，实验室指标,和生存期。从研究指标的总体分组进行统计分析，其中包括人口，孩子们,和成年人。
■在整个人口中，性别,年龄,血肌红蛋白,M-HLH与非M-HLH患者的NK细胞比值(P<0.05),血清白蛋白,和直接胆红素是M-HLH的独立相关因素。在儿科组，M-HLH与非M-HLH患者的年龄和NK细胞比例差异有统计学意义（P<0.05）。多因素Logistic回归分析显示,各因素均与M-HLH无显著相关性。相关回归分析显示,各因素均与M-HLH无显著相关性。ROC曲线分析显示,NK细胞百分比对M-HLH诊断在总体人群中的最佳预测价值在儿科组为4.96%,在成年期组为4.96%。对M-HLH诊断的最佳预测价值为2.08%。单因素分析显示血小板计数,丙氨酸氨基转移酶，天冬氨酸转氨酶,血清白蛋白,直接胆红素和间接胆红素影响预后；COX回归显示这些因素均无显著关系。成人组的总体中位生存时间为20.7个月，非M-HLH患者44.3个月，M-HLH患者7．73个月（p＝0．011）；单因素分析显示血小板计数和血清白蛋白水平影响预后；血清白蛋白水平COX回归结果是影响预后的独立危险因素。
■非M-HLH的存活率明显优于M-HLH；NK细胞比例对M-HLH的诊断具有预测价值；在普通人群中，非M-HLH比M-HLH更容易出现肝功能异常：血小板计数和血清白蛋白水平降低与预后不良相关。血小板计数和血清白蛋白水平越低，预后越差：此外，血清白蛋白水平较低的成年人也与预后不良相关.
■为了研究一些临床，病因学，和HLH的预后特征，以提高临床对疾病的认识。
■回顾性分析2015年6月至2021年8月我院收治的125例HLH患者的临床资料，包括临床特征，实验室指标,和生存期。从研究指标的总体分组进行统计分析，其中包括人口，孩子们,和成年人。
■在整个人口中，性别,年龄,血肌红蛋白,M-HLH与非M-HLH患者的NK细胞比值(P<0.05),血清白蛋白,和直接胆红素是M-HLH的独立相关因素。在儿科组，M-HLH与非M-HLH患者的年龄和NK细胞比例差异有统计学意义（P<0.05）。多因素Logistic回归分析显示,各因素均与M-HLH无显著相关性。相关回归分析显示,各因素均与M-HLH无显著相关性。ROC曲线分析显示,NK细胞百分比对M-HLH诊断在总体人群中的最佳预测价值在儿科组为4.96%,在成年期组为4.96%。对M-HLH诊断的最佳预测价值为2.08%。单因素分析显示血小板计数,丙氨酸氨基转移酶，天冬氨酸转氨酶,血清白蛋白,直接胆红素和间接胆红素影响预后；COX回归显示这些因素均无显著关系。成人组的总体中位生存时间为20.7个月，非M-HLH患者44.3个月，M-HLH患者7．73个月（p＝0．011）；单因素分析显示血小板计数和血清白蛋白水平影响预后；血清白蛋白水平COX回归结果是影响预后的独立危险因素。
■非M-HLH的存活率明显优于M-HLH；NK细胞比例对M-HLH的诊断具有预测价值；在普通人群中，非M-HLH比M-HLH更容易出现肝功能异常：血小板计数和血清白蛋白水平降低与预后不良相关。血小板计数和血清白蛋白水平越低，预后越差：此外，血清白蛋白水平较低的成年人也与预后不良相关.
