Abstract：
Objective.Alternating electric fields (AEF) therapy is a treatment modality for patients with glioblastoma. Tumor characteristics such as size, location, and extent of peritumoral edema may affect the AEF strength and distribution. We evaluated the sensitivity of the AEFs in a realistic 3D rat glioma model with respect to these properties.Approach.The electric properties of the peritumoral edema were varied based on calculated and literature-reported values. Models with different tumor composition, size, and location were created. The resulting AEFs were evaluated in 3D rat glioma models.Main results.In all cases, a pair of 5 mm diameter electrodes induced an average field strength >1 V cm-1. The simulation results showed that a negative relationship between edema conductivity and field strength was found. As the tumor core size was increased, the average field strength increased while the fraction of the shell achieving >1.5 V cm-1decreased. Increasing peritumoral edema thickness decreased the shell\'s mean field strength. Compared to rostrally/caudally, shifting the tumor location laterally/medially and ventrally (with respect to the electrodes) caused higher deviation in field strength.Significance.This study identifies tumor properties that are key drivers influencing AEF strength and distribution. The findings might be potential preclinical implications.
摘要：
目的：交变电场（AEF）治疗是胶质母细胞瘤患者的一种治疗方式。肿瘤特征，如大小，location,瘤周水肿的程度可能影响AEF的强度和分布。我们在真实的3D大鼠神经胶质瘤模型中评估了AEFs对这些特性的敏感性。
方法：根据计算值和文献报道值改变瘤周水肿的电特性。具有不同肿瘤组成的模型，尺寸,和位置被创建。在3D大鼠神经胶质瘤模型中评价所得的AEFs。
结果：在所有情况下，一对5mm直径的电极感应出平均场强>1V/cm。模拟结果表明，水肿电导率与场强之间存在负相关关系。随着肿瘤核心大小的增加，平均场强增加，而实现>1.5V/cm的壳的部分减少。肿瘤周围水肿厚度的增加降低了外壳的平均场强。与头端/尾端相比，侧向/内侧和腹侧（相对于电极）移动肿瘤位置会导致更高的场强偏差。
结论：本研究确定了肿瘤特性是影响AEF强度和分布的关键驱动因素。这些发现可能具有潜在的临床前意义。
方法：根据计算值和文献报道值改变瘤周水肿的电特性。具有不同肿瘤组成的模型，尺寸,和位置被创建。在3D大鼠神经胶质瘤模型中评价所得的AEFs。
结果：在所有情况下，一对5mm直径的电极感应出平均场强>1V/cm。模拟结果表明，水肿电导率与场强之间存在负相关关系。随着肿瘤核心大小的增加，平均场强增加，而实现>1.5V/cm的壳的部分减少。肿瘤周围水肿厚度的增加降低了外壳的平均场强。与头端/尾端相比，侧向/内侧和腹侧（相对于电极）移动肿瘤位置会导致更高的场强偏差。
结论：本研究确定了肿瘤特性是影响AEF强度和分布的关键驱动因素。这些发现可能具有潜在的临床前意义。
