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Abstract：
BACKGROUND: Early diagnostic and treatment advances have resulted in prolonged cancer survivorship. Therefore, exercise intervention in survivorship management is essential for enhancing cancer survivors\' health-related quality of life (HRQoL).
OBJECTIVE: The systematic review and meta-analysis in this study aimed to explore the effect of exercise intervention on health-related quality of life of colorectal cancer survivors.
METHODS: The current study followed guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 (PRISMA 2020) to identify relevant literature. Comprehensive searches were conducted using EBSCOhost, Web of Science (WOS), Scopus, Science Direct, and PubMed. The inclusion criteria included are randomised control trials studies written in English, with no restrictions for the time of publication that reported the effects of exercise intervention on health-related quality of live among colorectal cancer survivors. Meta-analysis was conducted by pooling the mean and standard deviation of post-intervention scores across randomised control trial studies using a random effects model.
RESULTS: A total of 467 articles were identified but only seven articles were randomised control trials (RCT) (n = 7) with PEDro scores ranging from 6 to 9 showing good internal validity were included in the review. The results of the meta-analysis of pooled data from six RCTs studies on HRQoL showed no significant effect of exercise intervention on HRQoL in the intervention group compared to control group [SMD = 0.25; 95% CI; -0.0, 0.51; Z = 1.88; p = 0.06; I2 = 30.8%].
CONCLUSIONS: This meta-analysis provides key insights into the effect of exercise on the health-related quality of life (HRQoL) of colorectal cancer (CRC) survivors. Therefore, more experimental studies should be carried out with rigorous methodology to evaluate the effectiveness of exercise interventions before it is recommended as a routine activity in post-treatment management for CRC survivors.
OBJECTIVE: The systematic review and meta-analysis in this study aimed to explore the effect of exercise intervention on health-related quality of life of colorectal cancer survivors.
METHODS: The current study followed guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 (PRISMA 2020) to identify relevant literature. Comprehensive searches were conducted using EBSCOhost, Web of Science (WOS), Scopus, Science Direct, and PubMed. The inclusion criteria included are randomised control trials studies written in English, with no restrictions for the time of publication that reported the effects of exercise intervention on health-related quality of live among colorectal cancer survivors. Meta-analysis was conducted by pooling the mean and standard deviation of post-intervention scores across randomised control trial studies using a random effects model.
RESULTS: A total of 467 articles were identified but only seven articles were randomised control trials (RCT) (n = 7) with PEDro scores ranging from 6 to 9 showing good internal validity were included in the review. The results of the meta-analysis of pooled data from six RCTs studies on HRQoL showed no significant effect of exercise intervention on HRQoL in the intervention group compared to control group [SMD = 0.25; 95% CI; -0.0, 0.51; Z = 1.88; p = 0.06; I2 = 30.8%].
CONCLUSIONS: This meta-analysis provides key insights into the effect of exercise on the health-related quality of life (HRQoL) of colorectal cancer (CRC) survivors. Therefore, more experimental studies should be carried out with rigorous methodology to evaluate the effectiveness of exercise interventions before it is recommended as a routine activity in post-treatment management for CRC survivors.
摘要：
背景：早期诊断和治疗的进展导致了癌症存活时间的延长。因此,生存管理中的运动干预对于提高癌症幸存者健康相关生活质量(HRQoL)至关重要。
目的：本研究的系统评价和荟萃分析旨在探讨运动干预对结直肠癌患者健康相关生活质量的影响。
方法：本研究遵循2020年系统评价和荟萃分析首选报告项目（PRISMA2020）中概述的指南，以确定相关文献。使用EBSCOhost进行了全面搜索，WebofScience(WOS),Scopus,科学直接，和PubMed。纳入标准包括以英语编写的随机对照试验研究，在报告运动干预对结直肠癌幸存者健康相关生活质量的影响的发表时间没有限制。使用随机效应模型，通过汇集随机对照试验研究的干预后得分的平均值和标准偏差进行荟萃分析。
结果：共确定了467篇文章，但只有7篇文章是随机对照试验（RCT）（n=7），PEDro评分在6到9之间，显示出良好的内部有效性。对来自六项RCTsHRQoL研究的汇总数据进行荟萃分析的结果显示，与对照组相比，干预组的运动干预对HRQoL没有显着影响[SMD=0.25；95％CI；-0.0，0.51；Z=1.88；p=0.06；I2=30.8％]。
结论：这项荟萃分析提供了关于运动对结直肠癌（CRC）幸存者健康相关生活质量（HRQoL）影响的关键见解。因此,在推荐运动干预作为CRC幸存者治疗后管理的常规活动之前,应采用严格的方法学开展更多的实验研究,以评估运动干预的有效性.
目的：本研究的系统评价和荟萃分析旨在探讨运动干预对结直肠癌患者健康相关生活质量的影响。
方法：本研究遵循2020年系统评价和荟萃分析首选报告项目（PRISMA2020）中概述的指南，以确定相关文献。使用EBSCOhost进行了全面搜索，WebofScience(WOS),Scopus,科学直接，和PubMed。纳入标准包括以英语编写的随机对照试验研究，在报告运动干预对结直肠癌幸存者健康相关生活质量的影响的发表时间没有限制。使用随机效应模型，通过汇集随机对照试验研究的干预后得分的平均值和标准偏差进行荟萃分析。
结果：共确定了467篇文章，但只有7篇文章是随机对照试验（RCT）（n=7），PEDro评分在6到9之间，显示出良好的内部有效性。对来自六项RCTsHRQoL研究的汇总数据进行荟萃分析的结果显示，与对照组相比，干预组的运动干预对HRQoL没有显着影响[SMD=0.25；95％CI；-0.0，0.51；Z=1.88；p=0.06；I2=30.8％]。
结论：这项荟萃分析提供了关于运动对结直肠癌（CRC）幸存者健康相关生活质量（HRQoL）影响的关键见解。因此,在推荐运动干预作为CRC幸存者治疗后管理的常规活动之前,应采用严格的方法学开展更多的实验研究,以评估运动干预的有效性.
