PDF(Pubmed)
Abstract：
OBJECTIVE: The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years.
METHODS: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D, sex, and country.
RESULTS: A total of 778 (9.2) children developed at least one autoantibody (any IA), and 335 (3.9%) developed multiple autoantibodies. 280 (3.3%) children had IAA and 319 (3.8%) GADA as the first autoantibody. 344 (44%) children with IA progressed to T1D. We observed that higher intake of niacin was associated with a decreased risk of developing multiple autoantibodies (HR 0.95; 95% CI 0.92, 0.98) per 1 mg/1000 kcal in niacin intake. Higher intake of pyridoxine (HR 0.66; 95% CI 0.46, 0.96) and vitamin B12 (HR 0.87; 95% CI 0.77, 0.97) was associated with a decreased risk of IAA-first autoimmunity. Higher intake of riboflavin (HR 1.38; 95% CI 1.05, 1.80) was associated with an increased risk of GADA-first autoimmunity. There were no associations between any of the B vitamins and the outcomes \"any IA\" and progression from IA to T1D. CONCLUSION: In this multinational, prospective birth cohort of children with genetic susceptibility to T1D, we observed some direct and inverse associations between different B vitamins and risk of IA.
METHODS: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D, sex, and country.
RESULTS: A total of 778 (9.2) children developed at least one autoantibody (any IA), and 335 (3.9%) developed multiple autoantibodies. 280 (3.3%) children had IAA and 319 (3.8%) GADA as the first autoantibody. 344 (44%) children with IA progressed to T1D. We observed that higher intake of niacin was associated with a decreased risk of developing multiple autoantibodies (HR 0.95; 95% CI 0.92, 0.98) per 1 mg/1000 kcal in niacin intake. Higher intake of pyridoxine (HR 0.66; 95% CI 0.46, 0.96) and vitamin B12 (HR 0.87; 95% CI 0.77, 0.97) was associated with a decreased risk of IAA-first autoimmunity. Higher intake of riboflavin (HR 1.38; 95% CI 1.05, 1.80) was associated with an increased risk of GADA-first autoimmunity. There were no associations between any of the B vitamins and the outcomes \"any IA\" and progression from IA to T1D. CONCLUSION: In this multinational, prospective birth cohort of children with genetic susceptibility to T1D, we observed some direct and inverse associations between different B vitamins and risk of IA.
摘要：
目的：目的是研究儿童饮食摄入B族维生素与10岁时胰岛自身免疫（IA）和1型糖尿病（T1D）进展风险之间的关系。
方法：我们追踪了8500名在美国出生的T1D易感儿童，芬兰,瑞典,和德国在2004-2010年从Young糖尿病的环境决定因素（TEDDY）研究中，这是一个前瞻性观察出生队列。根据3个月时的24小时召回和6个月至10岁定期收集的3天食物记录，从食物和膳食补充剂中计算出7种B族维生素的饮食摄入量。Cox比例风险模型进行了能量调整，HLA基因型，与T1D的一级相对，性别,和国家。
结果：共有778（9.2）名儿童出现了至少一种自身抗体（任何IA），335（3.9％）产生了多种自身抗体。280名（3.3％）儿童将IAA和319名（3.8％）GADA作为第一自身抗体。344名（44%）IA儿童进展为T1D。我们观察到，烟酸摄入量较高与每1mg/1000kcal摄入烟酸产生多种自身抗体（HR0.95;95％CI0.92，0.98）的风险降低相关。吡哆醇（HR0.66;95％CI0.46，0.96）和维生素B12（HR0.87;95％CI0.77，0.97）的较高摄入量与IAA首次自身免疫风险降低相关。较高的核黄素摄入量(HR1.38;95%CI1.05,1.80)与GADA-first自身免疫风险增加相关。任何B族维生素与结果“任何IA”和从IA到T1D的进展之间没有关联。结论：在这个跨国公司中，具有T1D遗传易感性的儿童的前瞻性出生队列，我们观察到不同B族维生素与IA风险之间存在一些正相关和负相关。
方法：我们追踪了8500名在美国出生的T1D易感儿童，芬兰,瑞典,和德国在2004-2010年从Young糖尿病的环境决定因素（TEDDY）研究中，这是一个前瞻性观察出生队列。根据3个月时的24小时召回和6个月至10岁定期收集的3天食物记录，从食物和膳食补充剂中计算出7种B族维生素的饮食摄入量。Cox比例风险模型进行了能量调整，HLA基因型，与T1D的一级相对，性别,和国家。
结果：共有778（9.2）名儿童出现了至少一种自身抗体（任何IA），335（3.9％）产生了多种自身抗体。280名（3.3％）儿童将IAA和319名（3.8％）GADA作为第一自身抗体。344名（44%）IA儿童进展为T1D。我们观察到，烟酸摄入量较高与每1mg/1000kcal摄入烟酸产生多种自身抗体（HR0.95;95％CI0.92，0.98）的风险降低相关。吡哆醇（HR0.66;95％CI0.46，0.96）和维生素B12（HR0.87;95％CI0.77，0.97）的较高摄入量与IAA首次自身免疫风险降低相关。较高的核黄素摄入量(HR1.38;95%CI1.05,1.80)与GADA-first自身免疫风险增加相关。任何B族维生素与结果“任何IA”和从IA到T1D的进展之间没有关联。结论：在这个跨国公司中，具有T1D遗传易感性的儿童的前瞻性出生队列，我们观察到不同B族维生素与IA风险之间存在一些正相关和负相关。
