PDF(Pubmed)
Abstract：
Acute gastroenteritis (AGE) in children can be attributed to a multitude of bacterial and viral pathogens. The objective of this study was to investigate the epidemiology of bacterial and viral AGE in children and to compare clinical characteristics between single and multiple enteric pathogen infections. A total of 456 stool samples were collected from outpatient children under 5 years old with AGE, which were subsequently analyzed for nine bacteria and three viruses using the Luminex xTAG® Gastrointestinal Pathogen Panel. The presence of at least one pathogen was detected in 260 cases (57.0%), with Salmonella being the predominant agent, followed by norovirus, Campylobacter, and rotavirus. A total of 69 cases (15.1%) exhibited positive results for two or more enteric pathogens. Although certain co-infections demonstrated significant differences in primary clinical features compared with mono-infections, no statistical variance was observed in terms of disease severity. In outpatient children from southern China, Salmonella emerged as the most prevalent causative agent of AGE, succeeded by norovirus and Campylobacter. This study underscores the burden posed by coinfections and highlights the clinical characteristics associated with AGE when accompanied by coinfections among children under 5 years old.
摘要：
儿童急性胃肠炎（AGE）可归因于多种细菌和病毒病原体。这项研究的目的是调查儿童细菌和病毒AGE的流行病学，并比较单个和多个肠道病原体感染的临床特征。从5岁以下年龄的门诊儿童中收集了456份粪便样本，随后使用LuminexxTAG®胃肠道病原体小组分析了9种细菌和3种病毒。在260例（57.0%）中检测到至少一种病原体的存在，沙门氏菌是主要病原体，其次是诺如病毒,弯曲杆菌,和轮状病毒。共有69例（15.1%）对两种或两种以上的肠道病原体表现出阳性结果。尽管某些合并感染与单一感染相比，在主要临床特征上存在显着差异，在疾病严重程度方面未观察到统计学差异.在中国南方的门诊儿童中，沙门氏菌是AGE最常见的病原体，诺如病毒和弯曲杆菌成功。这项研究强调了合并感染带来的负担，并强调了5岁以下儿童合并感染时与AGE相关的临床特征。
