Abstract：
BACKGROUND: Although arterial stiffness has been suggested to be associated with poor physical function and mild cognitive impairment (MCI), its association with cognitive frailty (CF), a comorbidity of both, is unclear. This study aims to examine the association between CF and arterial stiffness in community-dwelling older adults.
METHODS: A cross-sectional analysis of 511 community-dwelling older adults aged 65 years or older (mean age 73.6 ± 6.2 years, 63.6% women), who participated in a community cohort study (Tarumizu Study, 2019), was conducted. Poor physical function was defined as either slowness (walking speed <1.0 m/s) or weakness (grip strength <28 kg for men and <18 kg for women). MCI was defined by the National Center for Geriatrics and Gerontology Functional Assessment Tool as a decline of at least 1.5 standard deviation from age- and education-adjusted baseline values in any one of the four cognitive domains (memory, attention, executive, and information processing). CF was defined as the combination of poor physical function and MCI. Arterial stiffness was measured using the Cardio-Ankle Vascular Index (CAVI), and the average of the left and right sides (mean CAVI) was used.
RESULTS: Multinomial logistic regression analysis adjusted for covariates was performed with the four groups of robust, poor physical function, MCI, and CF as dependent variables and mean CAVI as an independent variable. Using the robust group as reference, the poor physical function and MCI groups showed no significant relationship with the mean CAVI. The mean CAVI was significantly higher in the CF group (odds ratio 1.62, 95% confidence interval: 1.14-2.29).
CONCLUSIONS: A significant association was found between CF and the higher CAVI (progression of arterial stiffness). Careful observation and control of CAVI, which is also an indicator of arterial stiffness, may be a potential target for preventive interventions for CF.
METHODS: A cross-sectional analysis of 511 community-dwelling older adults aged 65 years or older (mean age 73.6 ± 6.2 years, 63.6% women), who participated in a community cohort study (Tarumizu Study, 2019), was conducted. Poor physical function was defined as either slowness (walking speed <1.0 m/s) or weakness (grip strength <28 kg for men and <18 kg for women). MCI was defined by the National Center for Geriatrics and Gerontology Functional Assessment Tool as a decline of at least 1.5 standard deviation from age- and education-adjusted baseline values in any one of the four cognitive domains (memory, attention, executive, and information processing). CF was defined as the combination of poor physical function and MCI. Arterial stiffness was measured using the Cardio-Ankle Vascular Index (CAVI), and the average of the left and right sides (mean CAVI) was used.
RESULTS: Multinomial logistic regression analysis adjusted for covariates was performed with the four groups of robust, poor physical function, MCI, and CF as dependent variables and mean CAVI as an independent variable. Using the robust group as reference, the poor physical function and MCI groups showed no significant relationship with the mean CAVI. The mean CAVI was significantly higher in the CF group (odds ratio 1.62, 95% confidence interval: 1.14-2.29).
CONCLUSIONS: A significant association was found between CF and the higher CAVI (progression of arterial stiffness). Careful observation and control of CAVI, which is also an indicator of arterial stiffness, may be a potential target for preventive interventions for CF.
摘要：
虽然动脉僵硬度被认为与身体功能差和轻度认知障碍（MCI）有关，它与认知脆弱(CF)的关系，两者的共病，不清楚。本研究旨在研究社区居住老年人的CF与动脉僵硬度之间的关系。方法对511名65岁或以上的社区老年人进行横断面分析（平均年龄73.6±6.2岁，63.6%女性)，参加了一项社区队列研究(Tarumizu研究，2019),进行了。身体机能差定义为缓慢(步行速度<1.0米/秒)，或弱点（男性握力<28公斤，女性<18公斤）。MCI由国家老年医学和老年学功能评估工具中心定义为四个认知领域中任何一个（记忆，注意,Executive,和信息处理)。CF被定义为身体功能差和MCI的组合。使用心踝血管指数（CAVI）测量动脉僵硬度，并使用左侧和右侧的平均值（平均CAVI）。结果对协变量进行了多项logistic回归分析，身体机能差,MCI和CF作为因变量，平均CAVI作为自变量。使用健壮的组作为参考，身体功能差和MCI组与平均CAVI没有显着关系。CF组的平均CAVI明显更高（比值比1.62，95％置信区间1.14-2.29）。结论CF与较高的CAVI（动脉僵硬度的进展）之间存在显着关联。仔细观察和控制CAVI，这也是动脉僵硬度的指标，可能是CF预防性干预的潜在目标。
