PDF(Pubmed)
Abstract：
Surveillance for emerging pathogens is critical for developing early warning systems to guide preparedness efforts for future outbreaks of associated disease. To better define the epidemiology and burden of associated respiratory disease and acute flaccid myelitis (AFM), as well as to provide actionable data for public health interventions, we developed a multimodal surveillance program in Colorado, USA, for enterovirus D68 (EV-D68). Timely local, state, and national public health outreach was possible because prospective syndromic surveillance for AFM and asthma-like respiratory illness, prospective clinical laboratory surveillance for EV-D68 among children hospitalized with respiratory illness, and retrospective wastewater surveillance led to early detection of the 2022 outbreak of EV-D68 among Colorado children. The lessons learned from developing the individual layers of this multimodal surveillance program and how they complemented and informed the other layers of surveillance for EV-D68 and AFM could be applied to other emerging pathogens and their associated diseases.
摘要：
对新兴病原体的监测对于开发预警系统以指导未来相关疾病爆发的准备工作至关重要。为了更好地定义相关呼吸系统疾病和急性弛缓性脊髓炎（AFM）的流行病学和负担，以及为公共卫生干预提供可操作的数据，我们在科罗拉多州开发了一个多模式监测项目，美国,肠道病毒D68（EV-D68）。及时的本地,state,和国家公共卫生宣传是可能的，因为AFM和哮喘样呼吸道疾病的前瞻性综合征监测，在患有呼吸系统疾病的住院儿童中进行EV-D68的前瞻性临床实验室监测，和回顾性废水监测导致在科罗拉多州儿童中及早发现2022年爆发的EV-D68。从开发这种多模式监测计划的各个层次中吸取的经验教训，以及它们如何补充和告知EV-D68和AFM的其他监测层，可以应用于其他新兴病原体及其相关疾病。
