PDF(Pubmed)
Abstract：
Inositol phosphates and their metabolites play a significant role in several biochemical pathways, gene expression regulation, and phosphate homeostasis. Among the different inositol phosphates, inositol hexakisphosphate (IP6) is a substrate of inositol hexakisphosphate kinases (IP6Ks), which phosphorylate one or more of the IP6 phosphate groups. Pyrophosphorylation of IP6 leads to the formation of inositol pyrophosphates, high-energy signaling molecules that mediate physiological processes through their ability to modify target protein activities, either by directly binding to their target protein or by pyrophosphorylating protein serine residues. 5-diphosphoinositol pentakisphosphate, the most abundant inositol pyrophosphate in mammals, has been extensively studied and found to be significantly involved in a wide range of physiological processes. Three IP6K (IP6K1, IP6K2, and IP6K3) isoforms regulate IP7 synthesis in mammals. Here, we summarize our current understanding of IP6K1\'s roles in cytoskeletal remodeling, trafficking, cellular migration, metabolism, gene expression, DNA repair, and immunity. We also briefly discuss current gaps in knowledge, highlighting the need for further investigation.
摘要：
肌醇磷酸及其代谢产物在几种生化途径中起着重要作用，基因表达调控，和磷酸盐稳态。在不同的肌醇磷酸酯中，肌醇六磷酸（IP6）是肌醇六磷酸激酶（IP6Ks）的底物，其磷酸化一个或多个IP6磷酸基团。IP6的焦磷酸化导致肌醇焦磷酸盐的形成，高能信号分子通过其改变靶蛋白活性的能力来介导生理过程，通过直接结合它们的靶蛋白或通过焦磷酸化蛋白丝氨酸残基。5-二磷酸肌醇五磷酸，哺乳动物中最丰富的肌醇焦磷酸盐，已被广泛研究，并发现显着参与广泛的生理过程。三种IP6K（IP6K1，IP6K2和IP6K3）同工型调节哺乳动物IP7的合成。这里,我们总结了我们目前对IP6K1在细胞骨架重塑中的作用的理解，贩运，细胞迁移，新陈代谢，基因表达，DNA修复,和豁免权。我们还简要讨论了当前的知识差距，强调需要进一步调查。
