METHODS: A retrospective cohort study was conducted between 2010 and 2022 of children discharged with bacterial meningitis, using the Pediatric Health Information System\'s (PHIS) database. Rates of hearing loss and mortality were evaluated over time.
RESULTS: A total of 6138 children with a primary diagnosis of bacterial meningitis were identified (3520 male [57.3%], mean age 5.8 months [2.0, 61.2]). Of these, 277 (4.51%) were diagnosed with hearing loss. Children with hearing loss were significantly older (23.6 vs. 5.3 months, p < 0.01), but differences in gender, race, or ethnicity had no association with hearing loss. Streptococcus pneumoniae, Hemophilus influenzae, and Neisseria meningiditis were associated with significantly higher rates of hearing loss than other etiologies (p < 0.01). Children with hearing loss had a higher rate of receiving dexamethasone than children without hearing loss. Overall mortality rate was 2.1%. Hearing loss and mortality demonstrated significant decreases over the study period.
CONCLUSIONS: Hearing loss remains a common sequela of bacterial meningitis despite widespread uptake of vaccines for preventing S. pneumoniae, H. influenzae, and N. meningitidis. Dexamethasone was not associated with decreased rates of hearing loss in this cohort. From 2010 to 2022, there was a significant decrease in overall rates of mortality and hearing loss for children with bacterial meningitis.
METHODS: 3: retrospective case-control series Laryngoscope, 134:3820-3825, 2024.
方法:在2010年至2022年期间,对细菌性脑膜炎出院儿童进行了回顾性队列研究,使用儿科健康信息系统(PHIS)数据库。随着时间的推移,评估听力损失和死亡率。
结果:共有6138名初步诊断为细菌性脑膜炎的儿童(3520名男性[57.3%],平均年龄5.8个月[2.0,61.2])。其中,277例(4.51%)被诊断为听力损失。听力损失的儿童年龄明显较大(23.6vs.5.3个月,p<0.01),但是性别差异,种族,或种族与听力损失无关。肺炎链球菌,流感嗜血杆菌,与其他病因相比,脑膜炎奈瑟菌与听力损失的发生率明显更高(p<0.01)。有听力损失的儿童接受地塞米松的比率高于没有听力损失的儿童。总死亡率为2.1%。在研究期间,听力损失和死亡率显着下降。
结论:尽管广泛使用预防肺炎链球菌的疫苗,但听力损失仍然是细菌性脑膜炎的常见后遗症,流感嗜血杆菌,和脑膜炎奈瑟菌.在该队列中,地塞米松与听力损失率降低无关。从2010年到2022年,细菌性脑膜炎儿童的总体死亡率和听力损失显着下降。
方法:3级:回顾性病例对照系列喉镜,2024.