Abstract:
Professor Carlos Gutiérrez-Merino, a prominent scientist working in the complex realm of biological membranes, has made significant theoretical and experimental contributions to the field. Contemporaneous with the development of the fluid-mosaic model of Singer and Nicolson, the Förster resonance energy transfer (FRET) approach has become an invaluable tool for studying molecular interactions in membranes, providing structural insights on a scale of 1-10 nm and remaining important alongside evolving perspectives on membrane structures. In the last few decades, Gutiérrez-Merino\'s work has covered multiple facets in the field of FRET, with his contributions producing significant advances in quantitative membrane biology. His more recent experimental work expanded the ground concepts of FRET to high-resolution cell imaging. Commencing in the late 1980s, a series of collaborations between Gutiérrez-Merino and the authors involved research visits and joint investigations focused on the nicotinic acetylcholine receptor and its relation to membrane lipids, fostering a lasting friendship.
摘要:
CarlosGutiérrez-Merino教授,在复杂的生物膜领域工作的杰出科学家,为该领域做出了重要的理论和实验贡献。与Singer和Nicolson的流体镶嵌模型的发展同时,Förster共振能量转移(FRET)方法已成为研究膜中分子相互作用的宝贵工具,提供1-10nm范围内的结构见解,并在不断发展的膜结构观点中保持重要。在过去的几十年里,Gutiérrez-Merino\的工作涵盖了FRET领域的多个方面,他的贡献在定量膜生物学方面取得了重大进展。他最近的实验工作将FRET的基础概念扩展到高分辨率细胞成像。始于1980年代后期,Gutiérrez-Merino与作者之间的一系列合作涉及研究访问和联合调查,重点是烟碱乙酰胆碱受体及其与膜脂质的关系,培养持久的友谊。