PDF(Pubmed)
Abstract：
Endometriosis is a common gynecological condition with a complex physio-pathological background. This study aimed to assess the role of Rubus idaeus leaf extract (RiDE) as a potential therapeutic agent in reducing the size of the endometriotic lesions and modulate the plasma expression of MMP-2, MMP-9, and TGF-β1. The endometriotic lesions were induced in a rat model by the autologous transplant of endometrium. Thirty-six female rats, Wistar breed, with induced endometriosis, were divided into four groups and underwent treatment for 28 days. The CTRL group received 0.5 mL/day of the vehicle; the DG group received 1 mg/kg b.w./day dienogest; the RiDG group received 0.25 mL/kg b.w./day RiDE and the D+RiDG group received 1 mg/kg b.w./day dienogest and 0.25 mL/kg b.w./day RiDE, respectively. Rats\' weight, endometriotic lesion diameter and grade, and plasma levels of MMP-2, MMP-9, and TGF-β1 were assessed before and after treatment. The administration of RiDE in association with dienogest vs. dienogest determined a lower weight gain and a reduction in diameter of the endometriotic lesions. RiDE administration restored MMP2 and MMP9 plasma levels to initial conditions. Rubus idaeus extract may help in reducing dienogest-associated weight gain, lower the size of endometriotic lesions, and have anti-inflammatory effects through MMP2 and MMP9 reduction.
摘要：
子宫内膜异位症是一种常见的妇科疾病，具有复杂的生理病理背景。这项研究旨在评估悬钩子叶提取物（RiDE）作为一种潜在的治疗剂在减少子宫内膜异位病变的大小和调节MMP-2，MMP-9和TGF-β1的血浆表达中的作用。在大鼠模型中通过自体子宫内膜移植诱导子宫内膜异位病变。36只雌性老鼠,Wistar品种,诱发子宫内膜异位症，分为四组，治疗28天。CTRL组接受0.5mL/天的载体；DG组接受1mg/kgb.w./天的饮食；RiDG组接受0.25mL/kgb.w./天的饮食和DRiDG组接受1mg/kgb.w./天的饮食和0.25mL/kgb.w./天的饮食，分别。大鼠体重，子宫内膜异位病灶直径和级别,治疗前后测定血浆MMP-2、MMP-9和TGF-β1水平。与Dienogest和Dienogest确定了较低的体重增加和子宫内膜异位病变的直径减小。RiDE给药使MMP2和MMP9血浆水平恢复至初始条件。Rubusidaeus提取物可能有助于减少与饮食相关的体重增加，降低子宫内膜异位病灶的大小，并通过减少MMP2和MMP9具有抗炎作用。
