Improved Graft Function following Desensitization of Anti-AT1R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report.

抗 AT1R 和自身抗体脱敏后的移植功能改善患者供者特异性抗体阴性并伴有抗体介导的排斥反应 ： 病例报告。

• 影响指数: 6.208
• 发表时间: 2024 Feb 12
• 来源期刊: Int J Mol Sci
• DOI: 10.3390/ijms25042218
• PMID: 38396895
• 文章类型: Case Reports
• 中科院分区: Q2
• 方向: 生物
• 作者列表: Jung R,Ly K,Taniguchi M,Arriola AG,Gravante C,Shinn D,Mathew L,Hamad E,Geier S,Liacini A

关键词: AT1R; antibody-mediated rejection; autoantibodies; orthotopic heart transplantation; rejection

Mesh: Female; Humans; Middle Aged; Autoantibodies; Kidney Transplantation; HLA Antigens; Graft Rejection; Heart Transplantation / adverse effects

Abstract

HLA donor-specific antibodies (DSAs) pre and post transplant increase the risk of antibody-mediated rejection (AMR) and lead to poor graft survival. Increasing data exist to support the involvement of non-HLA antibodies in triggering an immunological response. The development of non-HLA antibodies specific for AT1R is associated with poor clinical outcomes in orthotopic heart transplant recipients. This case presents an investigation of non-HLA antibodies in a 56-year-old female heart transplant recipient diagnosed with AMR in the absence of DSAs.

摘要

移植前后HLA供体特异性抗体（DSA）会增加抗体介导的排斥反应（AMR）的风险，并导致移植物存活不良。越来越多的数据支持非HLA抗体参与触发免疫应答。对AT1R具有特异性的非HLA抗体的发展与原位心脏移植受体的不良临床结果相关。该病例介绍了在没有DSA的情况下诊断为AMR的56岁女性心脏移植受者中的非HLA抗体的研究。